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ArticleNeonatal atria and ventricles secrete atrial natriuretic factor via tissue-specific secretory pathways
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2023, JACC: Basic to Translational ScienceThe expression of natriuretic peptide receptors in developing zebrafish embryos
2018, Gene Expression PatternsDifferential expression and regulation of anti-hypertrophic genes Npr1 and Npr2 during β-adrenergic receptor activation-induced hypertrophic growth in rats
2016, Molecular and Cellular EndocrinologyCitation Excerpt :Our results are in agreement with the reports of Yoshimoto T et al., supporting the notion that an interaction between the β-AR signaling axis and ANP/NPR-A system in the heart could be the reason for the altered circulatory levels of ANP and CNP in the ISO induced hypertrophied rats (Yoshimoto et al., 1998). The ANP gene expression is absent or even undetectable in the adult ventricles (Bloch et al., 1986). However, several reports have demonstrated that the ventricle is capable of synthesizing and storing substantial amounts of ANP during cardiac hypertrophy and heart failure conditions (Thibault et al., 1989).
Oleanolic acid increases plasma ANP levels via an accentuation of cardiac ANP synthesis and secretion in rats
2013, European Journal of PharmacologySNARE protein regulation of cardiac potassium channels and atrial natriuretic factor secretion
2011, Journal of Molecular and Cellular CardiologyCitation Excerpt :This led to the discovery and cloning of ANF, BNP and CNP [63]. ANF secretion was then found to be elicited primarily by atrial stretch [59]; however, hormonal (endothelin-1) and α1-adrenergic stimulation also stimulate ANF release [61]. Hypertension, congestive heart and renal failure, and diabetes are associated with elevated plasma ANF levels [61].
Cardiac atria are the primary source of ANP release in hypoxia-adapted rats
2010, Life SciencesCitation Excerpt :Under baseline conditions, ANP and ANP mRNA levels in the cardiac atria are 1–2 orders of magnitude greater than in the ventricles. The cardiac atria synthesize large quantities of ANP that are stored in secretory granules and secreted via a regulatory pathway, whereas the ventricles secrete ANP via a constitutive pathway and have little pre-synthesized ANP stores (Bloch et al. 1986). Thus, under normal conditions the atria are considered the primary source of ANP release (Ruskoaho et al. 1987).