Cell
Nuclear protein migration involves two steps: Rapid binding at the nuclear envelope followed by slower translocation through nuclear pores
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Macromolecular Communication Between Nucleus and Cytoplasm
2022, Encyclopedia of Cell Biology: Volume 1-6, Second EditionIntracellular delivery of colloids: Past and future contributions from microinjection
2018, Advanced Drug Delivery ReviewsCitation Excerpt :Functionalized gold (Au) NP have been used in combination with electron or fluorescence microscopy to investigate subcellular organization [46, 119]. In a previously mentioned study where the two-step mechanism of nuclear entry was described for the first time [46], functionalized Au NP constituted a key tool. The attachment of the chaperone protein nucleoplasmin on the surface of the NP targeted them to the nuclear membrane, allowing observations that led to the above-described mechanism of nuclear entry [46].
AFM visualization of sub-50 nm polyplex disposition to the nuclear pore complex without compromising the integrity of the nuclear envelope
2016, Journal of Controlled ReleaseCitation Excerpt :The translocation of unpacked DNA from the cytoplasm to the nucleus is also debatable; it is expected to be slow and inefficient, since DNA is rapidly degraded in the cytoplasm with an apparent half-life of 50–90 min [15]. Nuclear entry, however, is a selective process tightly modulated by the nuclear pore complex (NPC) [16,17]. NPCs are supramolecular assemblies of nucleoporins displaying a ≤ 39 nm wide transport channel that mediates passive diffusion of molecules up to 40 kDa in size as well as facilitating selective transport of larger molecules bound to soluble transport receptors that shuttle between the cytoplasm and nucleus in eukaryotic cells [18,19].
An insertion in the methyltransferase domain of P. falciparum trimethylguanosine synthase harbors a classical nuclear localization signal
2016, Molecular and Biochemical ParasitologyMacromolecular Communication between Nucleus and Cytoplasm
2016, Encyclopedia of Cell Biology