Elsevier

Cell Calcium

Volume 18, Issue 6, December 1995, Pages 459-470
Cell Calcium

Review
The plasma membrane calcium pump - a physiological perspective on its regulation

https://doi.org/10.1016/0143-4160(95)90009-8Get rights and content

Abstract

This review focuses on the physiological role of the plasma membrane Ca2+ + Mg2+-dependent adenosine triphosphatase (PM Ca2+-ATPase) in cellular signalling. Particular attention has been paid to the regulation of the PM Ca2+-ATPase (PM Ca2+ + pump) by calmodulin, proteases, protein kinases, acidic phospholipids and oligomerization in intact cells. We also review recent work investigating the possible regulation of the PM Ca2+ pump by G proteins and agonists. The source of adenosine triphosphate (ATP) and Ca2+ in fuelling and activating the Ca 2+ pump is discussed, as well as the possible role of the PM Ca2+-ATPase in subplasmamembrane Cat+ regulation. The physiological implication of the localisation of the PM Ca2+ pump in caveolae is also considered.

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