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Taste memory: The role of protein synthesis in gustatory cortex

https://doi.org/10.1016/0163-1047(93)91145-DGet rights and content

Application of the protein synthesis inhibitor anisomycin to the rat gustatory cortex before and during training impairs conditioned taste aversion (CTA) to saccharin. No behavioral impairment is observed if the inhibitor is applied to an adjacent cortical area or to one cortical hemisphere only. The consumption of saccharin and of total fluid, as well as behavioral recognition of saccharin, is not affected. Preexposure of rats to saccharin several days before training markedly inhibits CTA to that taste. Injection of anisomycin to the gustatory cortex immediately prior to the preexposure period attenuates the latent inhibition. These results suggest that protein synthesis in the gustatory cortex is required for normal acquisition of the memory of taste.

References (36)

  • SquireL.R. et al.

    Inhibitors of cerebral protein synthesis: Dissociation of aversive and amnesic effects

    Behavioral Biology

    (1975)
  • AlkonD.L.

    Calcium-mediated reduction of ionic currents: A biophysical memory trace

    Science

    (1984)
  • BarberA.J. et al.

    Glycoprotein synthesis is necessary for memory of sickness-induced learning in chicks

    European Journal of Neuroscience

    (1989)
  • BraunJ.J.

    Gustatory cortex: Definition and function

  • BuresJ. et al.

    Brain and behavior: Paradigms for research in neural mechanisms

    (1988)
  • ChambersK.C.

    A neural model for conditioned taste aversion

  • ChristensenL.B. et al.

    Introduction to statistics for the social and behavioral sciences

    (1991)
  • DavisH.P. et al.

    Protein synthesis and memory: A review

    Psychological Bulletin

    (1984)
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    We are grateful to Shoshi Hazvi for skillful assistance in histological techniques, to Rina Schul for helpful comments, and to the Whitehall Foundation for support.

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