Transmission of immunoglobulin to foetal and neonatal mice
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Cited by (66)
Transplacental delivery of therapeutic proteins by engineered immunoglobulin G: a step toward perinatal replacement therapy
2023, Journal of Thrombosis and HaemostasisPreclinical evaluation of immunotherapeutic regimens for fetal/neonatal alloimmune thrombocytopenia
2021, Blood AdvancesCitation Excerpt :In contrast, in rodents, the majority of maternal IgG is delivered to pups postnatally in milk where, once ingested, it is transported by FcRn located on the surface of epithelial cells of the proximal small intestine.42 FcRn is notably absent from the placenta, with only small numbers of receptors present in the yolk sac endoderm,43 which results in inefficient antenatal transfer of Ig's from mother to fetus.44 That maternal anti-platelet antibodies can cause thrombocytopenia during gestation, before this report, was somewhat of an unresolved issue.
The Mammary Gland in Mucosal and Regional Immunity
2015, Mucosal Immunology: Fourth EditionA single, low dose oral antigen exposure in newborn piglets primes mucosal immunity if administered with CpG oligodeoxynucleotides and polyphosphazene adjuvants
2014, Veterinary Immunology and ImmunopathologyCitation Excerpt :Because the gut wall is closed after 1-2 days in ruminants, we suspect that the antigen likely did not cross the gut wall after this time period but this still means that the lambs received 2–3 doses of oral antigen (Rooke and Bland, 2002; Stott et al., 1979). The gut of the rat pup is permeable for 2 weeks after birth which means that the antigens may have crossed the gut wall in these animals and therefore these repeated doses may have contributed to induction of immunity (Appleby and Catty, 1983; Halliday, 1955b). It may be that repeated oral immunization in the immediate perinatal period (when the gut wall is permeable to maternal antibodies) may allow antigens to traverse the gut wall in an immunologically-intact form (Duizer et al., 1999; Roberton et al., 1982).
Mice congenitally infected with low-to-moderate virulence Neospora caninum isolates exhibited clinical reactivation during the mating period without transmission to the next generation
2013, Experimental ParasitologyCitation Excerpt :In this sense, the differences in N. caninum persistence in foetal-pup tissues could be due to the distinct placental structures (haemochorial versus synepitheliochorial) that determine a different maternal-foetal exchange (Entrican, 2002; Jiménez-Ruiz et al., 2013). Rodent pups acquire maternal antibodies placentally (Appleby and Catty, 1983), and these antibodies may be protective against infection in utero. Although EnTT has not been reproduced in experimentally infected cattle (Williams et al., 2000), employing other putative suitable species with a similar placenta structure, such as small ruminants, should be further analysed.
Transgenic Neospora caninum strains constitutively expressing the bradyzoite NcSAG4 protein proved to be safe and conferred significant levels of protection against vertical transmission when used as live vaccines in mice
2011, VaccineCitation Excerpt :Immunizations and the challenge injection were performed as reported by Aguado-Martinez et al. [33]. Dams and pups were sacrificed with CO2 gas on day 50 post-partum (P.P.) to evaluate the humoral immune response in the offspring without the interference of colostral antibodies [26,34]. Mice that did not become pregnant were left for a non pregnant mouse model (G6, G7, G8, G9 and G10) (Table 1).