Protein or RNA synthesis inhibition induces apoptosis of mature human CD4+ T cell blasts
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Carbon monoxide releasing molecule-2 CORM-2 represses global protein synthesis by inhibition of eukaryotic elongation factor eEF2
2013, International Journal of Biochemistry and Cell BiologyCitation Excerpt :Although it has been described that prevention of synthesis of potentially cytotoxic mediators such as inducible nitric oxide synthase or cyclooxygenase-2 is protective (Surh et al., 2001) and inhibition of translational initiation or elongation factors may lead to a targeted expression of specific cytoprotective proteins by eEF2/eIF independent mechanisms (Lopez-Lastra et al., 2005), a prolonged inhibition of general protein synthesis has been associated with cellular damage. For instance, lack of recovery from protein synthesis inhibition has been shown to correlate with neuronal death following brain ischemia and reperfusion (Degracia et al., 2002; Thilmann et al., 1986) and inhibition of protein synthesis may result in apoptosis (Lennon et al., 1990; Martin, 1993). Compared to carbon monoxide as a gas, CORMs are easier to handle and offer the advantage of tissue- and organ-specific delivery (Motterlini et al., 2002).
Lymphocyte activation associated antigens
2001, Methods in Cell BiologyInduction of apoptosis by mistletoe lectin I and its subunits. No evidence for cytotoxic effects caused by isolated A- and B-chains
2000, International Journal of Biochemistry and Cell BiologyUse of fusions to green fluorescent protein in the detection of apoptosis
2000, Methods in Enzymology