Review
Signal integration in the nervous system: adenylate cyclases as molecular coincidence detectors

https://doi.org/10.1016/0166-2236(94)90033-7Get rights and content

Abstract

Integrating multiple incoming messages simultaneously and discriminating ‘meaningful’ signals from spontaneous neural activity represent central problems to the nervous system. One mechanism by which signal integration and signal-to-noise resolution are achieved is the formation of temporal coincidence circuits by interacting transduction pathways. Signal integration via temporal coincidence detection is exemplified most readily by the way in which neural adenylate cyclases are regulated. This review will discuss the role of adenylate cyclases as coincidence detectors in the nervous system with special focus on adenylate cyclase type III, an isoenzyme that is found in large quantities in olfactory receptor neurons. The notion that olfactory transduction might also utilize an adenylate-cyclase-mediated temporal coincidence circuit strengthens the idea that signal integration via temporal-coincidence pathways is a universal feature of all neural adenylate cyclases.

References (47)

  • Y. Ishikawa

    J. Biol. Chem.

    (1992)
  • H.R. Bourne et al.

    Cell

    (1993)
  • B.K. Kaang et al.

    Neuron

    (1993)
  • L.R. Levin

    Cell

    (1992)
  • P.L. Han et al.

    Neuron

    (1992)
  • Z. Xia et al.

    Neuron

    (1991)
  • R.M. Huff et al.

    J. Biol. Chem.

    (1985)
  • R. Andrade

    Neuron

    (1993)
  • J.E. Amoore
  • L. Buck et al.

    Cell

    (1991)
  • G. Sicard et al.

    Brain Res.

    (1984)
  • P.B. Sklar et al.

    J. Biol. Chem.

    (1986)
  • S. Firestein et al.

    Neuron

    (1991)
  • S. Biffo et al.

    Mol. Brain Res.

    (1991)
  • T.V.P. Bliss et al.

    Nature

    (1993)
  • J. Krupinski

    Science

    (1989)
  • P.G. Feinstein
  • B. Gao et al.
  • S. Katsushika
  • R.T. Premont et al.
  • C.E. Glatt et al.

    Nature

    (1993)
  • H.A. Bakalyar et al.

    Science

    (1990)
  • E.R. Kandel et al.

    Science

    (1982)
  • Cited by (50)

    • Olfactory habituation in drosophila-odor encoding and its plasticity in the antennal lobe

      2014, Progress in Brain Research
      Citation Excerpt :

      In particular, the rutabaga mutant rut2080, a hypofunction allele, neither shows behavioral habituation nor diminished odor-evoked PN calcium transients after 4-day odor exposure, as observed in wild-type flies (Das et al., 2011). As the rutabaga gene encodes for a calcium–calmodulin-dependent adenylate cyclase (Levin et al., 1992; Livingstone et al., 1984) which are believed to act as coincidence detectors of G-protein signaling and neuronal depolarization (Anholt, 1994; Gervasi et al., 2010; Impey et al., 1994; Tomchik and Davis, 2009), this indicates a role of cAMP signaling in STH and LTH. Spatially and temporally controlled rutabaga transgene expression, achieved with the Gal4/UAS system combined with a Gal80ts construct (Brand and Perrimon, 1993; McGuire, 2003), indicates that rutabaga is required in a specific LN subset for olfactory habituation.

    View all citing articles on Scopus
    View full text