Trends in Neurosciences
ReviewSignal integration in the nervous system: adenylate cyclases as molecular coincidence detectors
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Olfactory habituation in drosophila-odor encoding and its plasticity in the antennal lobe
2014, Progress in Brain ResearchCitation Excerpt :In particular, the rutabaga mutant rut2080, a hypofunction allele, neither shows behavioral habituation nor diminished odor-evoked PN calcium transients after 4-day odor exposure, as observed in wild-type flies (Das et al., 2011). As the rutabaga gene encodes for a calcium–calmodulin-dependent adenylate cyclase (Levin et al., 1992; Livingstone et al., 1984) which are believed to act as coincidence detectors of G-protein signaling and neuronal depolarization (Anholt, 1994; Gervasi et al., 2010; Impey et al., 1994; Tomchik and Davis, 2009), this indicates a role of cAMP signaling in STH and LTH. Spatially and temporally controlled rutabaga transgene expression, achieved with the Gal4/UAS system combined with a Gal80ts construct (Brand and Perrimon, 1993; McGuire, 2003), indicates that rutabaga is required in a specific LN subset for olfactory habituation.