Research reportTransient impairment of cholinergic function in the rat insular cortex disrupts the encoding of taste in conditioned taste aversion
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2015, Neurobiology of Learning and MemoryCitation Excerpt :This raises the possibility that the greater subsequent avoidance responses could be due to non-specific malaise brought about by pairing the antagonist with the flavored solutions during training. Both LiCl-induced conditioned taste aversions and attenuation of neophobic responses were blocked by central SCOP pretreatment into the insular cortex (Ferreira, Gutierrez, De La Cruz, & Bermudez-Rattoni, 2002; Gutieerez, Tellez, & Bermudez-Rattoni, 2003; Gutierrez, Rodriguez-Ortiz, De La Cruz, Nunez-Jaramillo, & Bermudez-Rattoni, 2003; Naor & Dudai, 1996) and NAC shell (Ramirez-Lugo, Zavala-Vega, & Bermudez-Rattoni, 2006), but not when SCOP was administered after the presentation of the new taste. Although nicotinic receptor antagonists have not been evaluated in this paradigm, galantamine, an acetylcholinesterase inhibitor and positive allosteric modulator of nicotinic Ach receptors, reduced nicotine seeking without producing malaise (Hopkins, Rupprecht, Hayes, Blendy, & Schmidt, 2012).
Gustatory System
2015, The Rat Nervous System: Fourth Edition