Research reportA behavioral study of the development of hereditary cerebellar ataxia in the shaker rat mutant
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2023, IBRO Neuroscience ReportsCREB serine 133 is necessary for spatial cognitive flexibility and long-term potentiation
2022, NeuropharmacologyCitation Excerpt :Open field ± novel object, elevated plus maze, spontaneous alternation and serial spatial learning tasks were adapted from those reported in previous studies (Chen et al., 2000; D'Adamo et al., 2014; Oettinghaus et al., 2016; Pennucci et al., 2016; Daumas et al., 2017; Privitera et al., 2020). Assessment of neurological parameters was performed at P60 and was adapted from (Wolf et al., 1996). Mice were scored with 1 point for each neurological sign observed and 0 scores a fully healthy subject.
GDNF-induced cerebellar toxicity: A brief review
2016, NeuroToxicologyCitation Excerpt :Motor changes that might have been expected include ataxia, in particular gait ataxia, and tremor (Wolf et al., 1996; Tolbert et al., 2001; Sarna and Hawkes, 2003). A strong association appears to exist between the extent and type of spatial loss of Purkinje cells and the severity of clinical signs (Wolf et al., 1996). Therefore, the most likely explanation for the absence of motor changes in the study is the limited extent and random distribution of the lesions across the cerebellar cortex of the affected animals.
Behavioral effects of neonatal lesions on the cerebellar system
2015, International Journal of Developmental NeuroscienceCitation Excerpt :Shaker mutant rats are characterized by a semi-dominant chromosome X-linked mutation of an unknown gene (Clark et al., 2000), leading to Purkinje cell degeneration and ataxia (Tolbert et al., 1995). When tested on postnatal day 4, shaker mutant rats were marked by a delay in body righting, though normal values were attained on day 10 (Wolf et al., 1996). On the contrary, there was no intergroup difference in negative geotropism, mid-air righting, or cliff avoidance tests.