A quantitative study of neuropeptide immunoreactive cell bodies of primary afferent sensory neurons following rat sciatic nerve peripheral axotomy
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The impact of short-lasting repeated vibrations on retrograde axonal transport, the expression of CGRP and parvalbumin in lower lumbar dorsal root ganglia
2011, Brain ResearchCitation Excerpt :DRG sensory neurons can synthesize a wide variety of neuropeptides which can interact under certain circumstances. It has been also shown that many peptidergic DRG sensory neurons can switch the expression of one peptide to another one after injury, whereas non-peptide-containing subpopulations do not (Doughty et al., 1991). There is a large support that PV is a marker for fast firing neurons which have a high level of activity (Carr et al., 1989; Celio, 1984).
Activin acts with nerve growth factor to regulate calcitonin gene-related peptide mRNA in sensory neurons
2007, NeuroscienceCitation Excerpt :The addition of high levels of NGF (100 ng/ml) did not increase CGRP mRNA at 2 or 6 h (data not shown) but increases were detected at 24 h and CGRP mRNA levels continued to increase each day in this NGF concentration (Fig. 1A gray bars). While CGRP mRNA levels appear to decline with time without added NGF (Doughty et al., 1991; Shadiack et al., 2001) neuronal cell survival is known to remain high in these cultures (Omri and Meiri, 1990; Cruise, 2004), and indeed, GAPDH mRNA levels detected by real-time PCR remain similar (data not shown). From these data, we chose to examine CGRP regulation at 4 days in vitro to obtain robust and reproducible CGRP mRNA increases.
Extracorporeal shock wave therapy improves motor dysfunction and pain originating from knee osteoarthritis in rats
2007, Osteoarthritis and CartilageCitation Excerpt :A CGRP antagonist reduces the response of hyperexcitable spinal neurons to both innocuous and noxious pressure applied to the inflamed joint12. After sciatic nerve sectioning in the rat, CGRP-ir in DRG neurons was decreased13, and the rats demonstrated analgesia to heat stimuli. Furthermore, there was a significant decrease in the number of CGRP-ir DRG neurons in rofecoxib-treated rats, which was also correlated with behavioral data where hypersensitivity was significantly reduced4.
Application of shock waves to rat skin decreases calcitonin gene-related peptide immunoreactivity in dorsal root ganglion neurons
2003, Autonomic Neuroscience: Basic and ClinicalIncreased expression of vasoactive intestinal polypeptide in cultured myenteric neurons from adult rat small intestine
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2003, Neuropeptides
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Present address: I.C.I. Pharmaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.
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Present address: Department of Psychology, University of Sheffield, Western Bank, Sheffield S10 2TN, U.K.