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The pattern electroretinogram in Parkinson's disease reveals lack of retinal spatial tuning

https://doi.org/10.1016/0168-5597(95)00169-7Get rights and content

Abstract

Spatio-temporal visual abnormalities, involving processing of medium coarse stimuli, are known to occur in Parkinson's disease (PD). While these deficits have been related to retinal dopaminergic deficiency, previous ERG studies in PD patients have provided conflicting results, probably due to differences in stimulus conditions. The influence of pattern element size (spatial frequency, SF) on the pattern electroretinogram (PERG) in PD has not been systematically studied. We recorded steady-state PERG to sinusoidal gratings of 50% contrast, counterphase modulated at 7.5 Hz with a series of SFs ranging from 0.5 to 6.9 c/deg in 20 PD patients and 20 healthy volunteers, subdivided in 10 “young” and 10 “age-matched” (AM) subjects. The PERG was analyzed by means of Fast Fourier Transform and the amplitude and the phase of the second harmonic response (15 Hz) were taken into account. We evaluated the medium-to-low SF amplitude ratio and termed it “PERG tuning ratio” (TR). The results indicate that aging affects all the studied SF, but the pattern of age-related loss differs from that observed in PD. Compared to AM subjects, PD patients show a specific deficit at medium SF, with a distorted PERG SF response function. Consequently, all PD patients show an attenuated PERG TR and 17 of them (85%) have an inverted TR. A significant TR decrease is correlated with the clinical stage of PD. There is a marked TR difference between patients receiving and not receiving l-DOPA. We conclude that stimulus SF is a crucial variable of the PERG in PD. PERG measurements and the derived PERG TR may provide a simple tool to evaluate retinal dopaminergic mechanisms and could contribute to the clinical assessment and monitoring of dopaminergic therapy in PD.

References (62)

  • T. Tomita et al.

    Origins of the ERG waves

    Vision Res.

    (1981)
  • H. Tomoda et al.

    Effect of spatial frequency on simultaneous recorded steady-state pattern electroretinograms and visual evoked potentials

    Electroenceph. clin. Neurophysiol.

    (1991)
  • M.A. Zarbin et al.

    Autoradiographic localization of high affinity GABA, Benzodiazepine, Dopaminergic, Adrenergic and muscarinic cholinergic receptors in the rat, monkey and human retina

    Brain Res.

    (1986)
  • M. Bach et al.

    Check-size specific changes of pattern electroretinogram in patients with early open-angle glaucoma

    Doc. Ophthalmol.

    (1988)
  • M. Bach et al.

    Optic atrophy reduces the pattern-electroretinogram for both fine and coarse stimulus patterns

    Clin. Vision Sci.

    (1992)
  • C.L. Baker et al.

    Linear and non-linear component of human electroretinogram

    J. Neurophysiol.

    (1984)
  • I. Bodis-Wollner

    Visual acuity and contrast sensitivity in patients with cerebral lesions

    Science

    (1972)
  • I. Bodis-Wollner

    Visual deficits related to dopamine deficiency in experimental animals and Parkinson's disease

    Trends Neurosci.

    (1990)
  • I. Bodis-Wollner et al.

    Measurement of visual evoked potentials in Parkinson's disease

    Brain

    (1978)
  • I. Bodis-Wollner et al.

    On the possible role of temporal delays of afferent processing in Parkinson's disease

    J. Neural Transm.

    (1983)
  • I. Bodis-Wollner et al.

    Methodological aspects of signal-to-noise evaluation of simultaneous pattern electroretinogram and visual evoked potential recordings

  • I. Bodis-Wollner et al.

    Visual dysfunction in Parkinson's disease — loss in spatiotemporal contrast sensitivity

    Brain

    (1987)
  • I. Bodis-Wollner et al.

    The importance of physiology to visual evoked potentials

  • S. Calzetti et al.

    Simultaneous VEP and PERG investigations in early Parkinson's disease

    J. Neurol. Neurosurg. Psychiat.

    (1990)
  • G. Cavallacci et al.

    The interest of electroretinography in Parkinsonism

  • G. Celesia et al.

    Spatial frequency evoked visuograms in multiple sclerosis

    Neurology

    (1992)
  • S.G. Diamond et al.

    Effect of age at onset on progression and mortality in Parkinson's disease

    Neurology

    (1990)
  • L. Domenici et al.

    Dopaminergic drugs improve human visual contrast sensitivity

    Hum. Neurobiol.

    (1985)
  • J.E. Dowling et al.

    Synaptic organization of the amine-containing interplexiform cells of the goldfish and Cebus monkey retinas

    Science

    (1975)
  • C.J.K. Ellis et al.

    Retinal dopamine function in idiopathic Parkinson's disease

    Clin. Vision Sci.

    (1987)
  • B. Falsini et al.

    Follow-up study with pattern-ERG in ocular hypertension and glaucoma patients under timolol maleate treatment

    Clin. Vision Sci.

    (1992)
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