Research reportDistinctive four promoters collectively direct expression of brain-derived neurotrophic factor gene
References (30)
- et al.
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Anal. Biochem.
(1987) - et al.
BDNF mRNA expression in the developing rat brain following kainic acid-induced seizure activity
Neuron
(1992) - et al.
cDNA cloning and sequence determination of art membrane-associated phospholipase A2
Biochem. Biophys. Res. Commun.
(1989) - et al.
NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression
Neuron
(1990) - et al.
Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations
Genomics
(1991) - et al.
A cell type-preferred silencer element that controls the neural-specific expression of the SCG10 gene
Neuron
(1990) - et al.
Inflammatory factors stimulate expression of group II phospholipase A2 in rat cultured astrocytes
J. Biol. Chem.
(1991) - et al.
Neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs
Neuron
(1992) - et al.
BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease
Neuron
(1991) - et al.
The 5′-flanking region of the synapsin I gene
J. Biol. Chem.
(1990)
Characterization of the 5′-flanking region of the human brain-derived neurotrophic factor
Biochem. Biophys. Res. Commun.
Structure of the gene encoding peripherin, an NGF-regulated neuronal-specific type III intermediate filament protein
Neuron
Multiple promoters direct tissue-specific expression of the rat BDNF gene
Neuron
In situ hybridization with RNA probes: an annotated recipe
DNA binding site of the growth factor-inducible protein Zif268
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2016, Cell ReportsImmune dysregulation and cognitive vulnerability in the aging brain: Interactions of microglia, IL-1β, BDNF and synaptic plasticity
2015, NeuropharmacologyCitation Excerpt :All of the transcripts are found in the hippocampus, though at different levels, and with different cellular and subcellular distributions (An et al., 2008; Kokaia et al., 1994; Timmusk et al., 1993). Their expression is differentially regulated by a variety of inputs including alterations in neuronal activity (Metsis et al., 1993; Nakayama et al., 1994; Timmusk et al., 1993), exercise (e.g. (Garcia et al., 2003; Oliff et al., 1998)), treatment with antidepressants (Russo-Neustadt et al., 2004), and various stress paradigms (reviewed in (Lauterborn et al., 1998)). Infusion of IL-1β into the hippocampus decreased its capacity for transcription of BDNF following learning (Barrientos et al., 2004), and infusion of IL-1ra protected it from the deleterious effects of IL-1β induced by a social isolation stress paradigm (Barrientos et al., 2003).
Involvement of brain-derived neurotrophic factor in late-life depression
2013, American Journal of Geriatric PsychiatryCitation Excerpt :We further examined the molecular basis of decreased BDNF synthesis in response to CORT treatment. The rat bdnf gene contains four distinct promoters that are linked to four main transcript forms.100 Although the functions of each BDNF transcript are not clearly known, BDNF transcripts are differentially expressed across brain regions and are differentially regulated.101,102
Behavioral changes after maternal separation are reversed by chronic constant light treatment
2012, Brain ResearchCitation Excerpt :Treatment with escitalopram did not change the maternal separation-induced increase in BDNF levels. The BDNF gene has four transcript forms, which facilitate regulation of BDNF expression on many levels (Nakayama et al., 1994; Timmusk et al., 1993). The various receptor subtypes of the endogenous opioid system have been found to differentially mediate behavioral mood states.
Role of brain-derived neurotrophic factor in Huntington's disease
2007, Progress in Neurobiology