Research reportChlordiazepoxide attenuates stress-induced activation of neurons, corticotropin-releasing factor (CRF) gene transcription and CRF biosynthesis in the paraventricular nucleus (PVN)
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2015, NeuropharmacologyMidazolam treatment before re-exposure to contextual fear reduces freezing behavior and amygdala activity differentially in high- and low-anxiety rats
2015, Pharmacology Biochemistry and BehaviorCitation Excerpt :Accordingly, infusing the GABA-receptor agonist muscimol into the BLA impaired both extinction learning and fear renewal (Herry et al., 2008). Benzodiazepines have been demonstrated to suppress HPA axis activity, thus attenuating the stress-induced activation of neurons (as measured by CRF mRNA and c-Fos mRNA) and the anxiogenic effects of CRF (Krulik and Cerny, 1971; Britton et al., 1985; Swerdlow and Britton, 1994; Imaki et al., 1995). In the present study, midazolam attenuated re-conditioning-induced CRF expression in the MeA and plasma corticosterone concentration in the LR rats compared with those parameters in the control and HR groups.
Magnesium deficiency induces anxiety and HPA axis dysregulation: Modulation by therapeutic drug treatment
2012, NeuropharmacologyCitation Excerpt :In Mg2+ deficient mice, application of the benzodiazepine diazepam reduced the hyper-reactivity of the PVN in response to a mild emotional challenge. The ability of benzodiazepines to decrease stress-induced neuronal activation in the PVN has been previously shown in mice (Imaki et al., 1995) and rats (Beck and Fibiger, 1995; de Medeiros et al., 2005). Furthermore, chronic desipramine treatment via the drinking water normalised CRH overexpression in the PVN and elevated ACTH plasma levels.
Chlordiazepoxide and lavender oil alter unconditioned anxiety-induced c-fos expression in the rat brain
2011, Behavioural Brain ResearchCitation Excerpt :There are thus a number of reasons to expect that CDP would reduce anxiety and change c-fos expression as was found in the brain regions studied. The effect of CDP on c-fos expression in PVN replicates an earlier finding [29], where it was argued that CDP suppressed the cellular activation caused by CRF release and ACTH secretion. A different effect was seen in the CeA, where CDP promoted expression of c-fos after stress, as found previously [26,27,38].