Human metabotropic glutamate receptor type 7: Molecular cloning and mRNA distribution in the CNS

doi:10.1016/0169-328X(96)00110-6

Molecular Brain Research

Volume 40, Issue 1, August 1996, Pages 165-170

https://doi.org/10.1016/0169-328X(96)00110-6 Get rights and content

Abstract

Human metabotropic glutamate receptor type 7 (mGluR7) cDNA clones were isolated from a medulla cDNA library. The sequence, which includes a polymorphism, has 92% DNA sequence identity with rat mGluR7 and the predicted protein sequence has 99% identity. In-situ hybridization studies on human brain sections showed that mGluR7 mRnA has a widespread distribution with highest levels in the hippocampal formation, cerebral cortex and cerebellum.

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^☆: The nucleotide sequence reported in this paper has been submitted to the EMBL Data Bank with accession number X94552.

²: Present address: Clinical Pharmacology Unit, Department of Psychological Medicine, Institute of Psychiatry, Denmark Hill, London SE5 8AF, UK.

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Short communicationHuman metabotropic glutamate receptor type 7: Molecular cloning and mRNA distribution in the CNS☆

Abstract

J. Biol. Chem.

Neuropharmacology

Neuroscience

Neurosci. Lett.

Mol. Brain Res.

Mol. Brain Res.

Biochem. Biophys. Res. Comm.

Biochem. Biophys. Res. Commun.