Rapid paperLocalization of the Thy-1 antigen to the surfaces of rat retinal ganglion cells
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2015, Nanomedicine: Nanotechnology, Biology, and MedicineThy-1-interacting molecules and cellular signaling in Cis and Trans
2013, International Review of Cell and Molecular BiologyCitation Excerpt :However, Thy-1 is differentially expressed in the different types of neurons. For example, neurons with long processes, such as the RG cells, express Thy-1 at higher density than those with short processes, like the interneurons (Barnstable and Drager, 1984; Beale and Osborne, 1982; Morris et al., 1985; Weber et al., 1988). Thy-1 expression is also regulated during pre- and postnatal development.
Neuroprotective Effect of(-)Δ<sup>9</sup>-Tetrahydrocannabinol and Cannabidiol in N-Methyl-D-Aspartate-Induced Retinal Neurotoxicity: Involvement of Peroxynitrite
2003, American Journal of PathologyCitation Excerpt :The levels of Thy-1, neurofilament light (NF-L; MW 70 to 80 kd) and internal standard, 18S ribosomal RNA (rRNA), from total RNAs present in the retinas were determined with a comparative quantitative RT-PCR technique (Ambion Inc., Austin TX). Thy-1 antigen is primarily associated with retinal ganglion cells.32 NF-L is primarily associated with ganglion cell axons.33
Rat retinal ganglion cell loss caused by kainate, NMDA and ischemia correlates with a reduction in mRNA and protein of Thy-1 and neurofilament light
2003, Brain ResearchCitation Excerpt :A number of points are worth making concerning these results: firstly, the loss of NF-L mRNA after the three treatments mirrored very closely the loss of Thy-1 mRNA; secondly, the decrease in Thy-1 and NF-L mRNAs 1 day after NMDA injection is very similar to that found after 8 days; thirdly, the magnitude of the reduction in levels of Thy-1 and NF-L mRNAs after kainate is similar to that seen after NMDA but higher than after ischemia/reperfusion; and fourthly, rhodopsin levels were unchanged after NMDA and ischemia but somewhat higher after kainate injection. Previous work has demonstrated that Thy-1 immunoreactivity in the rat retina is associated exclusively with the inner plexiform and RGC layers, which contain the dendrites and cell bodies of the RGCs and the optic nerve axons [1,2,14]. Fig. 4A shows normal staining of Thy-1 in a control retina.
Effects of β-adrenergic blockers on glutamate-induced calcium signals in adult mouse retinal ganglion cells
2003, Brain ResearchCitation Excerpt :Our results indicate that antibody CD90.2 against Thy-1 can be used as a specific marker for mouse ganglion cells and optic nerves. This is consistent with the results obtained from the rodent retinas [16,17]. Since all axons are heavily stained, it is likely that at least a large portion of the CD90.2 positive cells are ganglion cells.