Invited review
Neurotransmitters as developmental signals

https://doi.org/10.1016/0197-0186(91)90113-RGet rights and content

Abstract

During recent years it has become increasingly clear that classical neurotransmitters such as monoamines and the amino acids glutamate and GABA affect the development and subsequent functional differentiation of neurons and astrocytes. The present review focuses on an outline of effects of these substances on cell morphology, enzyme activities and receptor expression. Moreover, the mechanisms for these effects are discussed and it is concluded that receptor activation is likely to be coupled to second messenger systems and regulation of intracellular Ca2+ levels.

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