ArticleDeterioration of spatial and nonspatial reference and working memory in aged rats: Protective effect of life-long calorie restriction
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2020, Mechanisms of Ageing and DevelopmentCitation Excerpt :Cognitive function and underlying cellular, molecular and physiological mechanisms are known to decline with age (Bettio et al., 2017; Clapp and Gazzaley, 2012; Padgaonkar et al., 2017). Long-term ER can reduce the learning and memory impairments in aged rats, compared to young adult rats as examined with the Morris water maze task (Adams et al., 2008; Pitsikas and Algeri, 1992; Rojic-Becker et al., 2019). Aged mice also show similar improvements in memory following long-term ER in several tasks, including the Morris water maze, the novel object recognition task as well as different operant tasks (Fontan-Lozano et al., 2007; Jeon et al., 2016; Ma et al., 2018; Wahl et al., 2018).
Time-restricted feeding (TRF) for prevention of age-related vascular cognitive impairment and dementia
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2020, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :Caloric restriction, a reduction in food consumption without malnutrition, is known to extend lifespan in many organisms (Pifferi and Aujard, 2019; Pistell et al., 2012; Rapp and Gallagher, 1996). Lifelong caloric restriction improves memory in aged rodents (Pitsikas and Algeri, 1992), an effect that might be caused by the improvement of NMDA receptors and LTP (Eckles-Smith et al., 2000a). Diet modulates the epigenome and growing evidence indicates that nutritional changes can modify age-related epigenetic marks (Gensous et al., 2019).
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