Age-related alterations in the properties of hippocampal pyramidal neurons among rat strains
References (33)
- et al.
Aging does not alter muscarinic receptor-mediated inhibition of cyclic AMP formation in the striatum and hippocampus
Brain Res.
(1990) - et al.
Increased [3H]glutamate receptor binding in aged rats
Brain Res.
(1981) - et al.
Muscarinic acetylcholine receptor subtype mRNA expression and ligand binding in the aged rat forebrain
Neurobiol. Aging
(1991) - et al.
Decreased density, but not number, of N-methyl-D-aspartate, glycine and phencyclidine binding sites in hippocampus of senescent rats
Brain Res.
(1990) The effect of aging on hippocampal and cortical projections of the forebrain cholinergic system
Brain Res. Rev.
(1987)- et al.
Calcium and the aging nervous system
Neurobiol. Aging
(1987) - et al.
Selective influence of rat genotype on age-related regional changes in forebrain muscarinic binding
Neurobiol. Aging
(1987) - et al.
Age-related changes in the cholinergic components within the central nervous system II. Working memory impairement and its relation to hippocampal muscarinic receptors
Mech. Ageing Develop.
(1990) - et al.
Intrinsic membrane potential oscillations in hippocampal neurons in vitro
Brain Res.
(1991) - et al.
Age-related alterations in neurotransmitter receptors. An electrophysiological and biochemical analysis
Neurobiol. Aging
(1981)
Conformational changes in muscarinic receptors may produce diminished cholinergic neurotransmission and memory deficits in aged rats
Neurobiol. Aging
Individual differences in aging: Behavioral and neurobiological correlates
Neurobiol. Aging
Age-related differences in brain choline acetyltransferase, cholinesterases and muscarinic receptor sites in two strains of rats
Neurobiol. Aging
Reversed ethanol effects on potassium conductances in aged hippocampal dentate granule neurons
Brain Res.
Cholinergic drug effects and brain muscarinic receptor binding in aged rats
Neurobiol. Aging
Strain-dependent decrease in glutamate binding to the N-methyl-D-aspartic acid receptor during aging
Neurosci. Lett.
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Different macaque models of cognitive aging exhibit task-dependent behavioral disparities
2018, Behavioural Brain ResearchCitation Excerpt :This is due in great part to the relatively large sample sizes necessary to draw meaningful conclusions. Such comparisons in rodents have revealed important disparities between species and even between strains of the same species at multiple levels of analysis [22–28]. In general, this has led the field to treat different rodents as distinct animal models.
Altered function of neuronal L-type calcium channels in ageing and neuroinflammation: Implications in age-related synaptic dysfunction and cognitive decline
2018, Ageing Research ReviewsCitation Excerpt :Hippocampal neurons show an age-related decrease in neuronal excitability and an increase in AHP is an important factor for reducing the excitability of neurons (Fig. 1b). Increased AHP in aged neurons is due to enhanced Ca2+ influx (Deyo et al., 1989; Disterhoft et al., 1996; Kerr et al., 1989; Landfield et al., 1989; Landfield and Pitler, 1984; Potier et al., 1993; Stutzmann et al., 2006). The enhanced AHP is due to Ca2+ influx through Cav1.3 channels as genetic deletion of Cav1.3 reduces, while deletion of Cav1.2 has no impact on AHP (Gamelli et al., 2011; McKinney et al., 2009).
FK506-binding protein 1b/12.6: A key to aging-related hippocampal Ca<sup>2+</sup> dysregulation?
2014, European Journal of PharmacologyCholinergic gating of hippocampal auditory evoked potentials in freely moving rats
2013, European NeuropsychopharmacologyCitation Excerpt :Firstly, the current study used Wistar rats whereas others used Sprague-Dawley rats (Campbell et al., 1995; Luntz-Leybman et al., 1992; Miyazato et al., 1995; Teneud et al., 2000). Strain differences may explain some differences between studies (e.g., Adler et al., 1986), but these appear to be minimal (e.g., Borg, 1982; Potier et al., 1993). However, even rats that belong to the same strain but have been obtained from different suppliers can show discrepancies in AEP components within the same experiment (e.g., Adler et al., 1986).
Age-related alterations of GABAergic input to CA1 Pyramidal neurons and its control by nicotinic acetylcholine receptors in rat hippocampus
2006, NeuroscienceCitation Excerpt :Other parameters were also not affected by aging, such as the amplitude of glutamatergic EPSPs, or I/O relationships for AMPA receptor-mediated synaptic transmission (not shown), indicating that the alterations of the GABAergic transmission described herein were specifically linked to aging. As previously observed (Landfield and Pitler, 1984; Potier et al., 1992, 1993; Moyer et al., 1992), the AHP duration was increased in aged rat hippocampal pyramidal neurons. However, this increase was not significant, as already reported (Potier et al., 1992, 1993).
Growth hormone treatment attenuates age-related changes in hippocampal short-term plasticity and spatial learning
2004, NeuroscienceCitation Excerpt :In more recent work, Papatheodoropoulos and Kostopoulos (1996) reported that excitability of CA1 neurons increases from 7 to 8 months to 30 months of age, as determined by increases in the rising slope of EPSPs that produced both the threshold and half-maximal population spike. However, changes in excitability of CA1 neurons are controversial, and several groups have reported diminished excitability with age (Moyer et al., 1992; Potier et al., 1993; Turner and Deupree, 1991). Furthermore, age-related decreases in AMPA receptor density and decreased depolarization in response to AMPA application have been consistently reported in the CA1 region.