Somatostatin in the central nervous system: Physiology and pathological modifications
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2023, Behavioural Brain ResearchCitation Excerpt :Our results show that there was no difference in mRNA levels of any of the analyzed genes in the hypothalamus between MS and control dams. Besides deiodinases, other factors can influence the TSH concentration in the organism, such as somatostatin and PAP-2 [15,29,68]. Our results show no differences in the mRNA expression of somatostatin or PAP-2 genes in the hypothalamus of either MS or control dams.
Adeno-associated viral vector-mediated preprosomatostatin expression suppresses induced seizures in kindled rats
2017, Epilepsy ResearchCitation Excerpt :Sustained adeno-associated viral (AAV) vector-mediated expression of galanin, neuropeptide Y or preprosomatostatin (preproSST) has been shown to delay epileptogenesis or suppress seizures in several animal models of TLE (Haberman et al., 2003; Kanter-Schlifke et al., 2007; Lin et al., 2003; McCown, 2006; Noè et al., 2008; Richichi et al., 2004; Sørensen et al., 2009; Woldbye et al., 2010; Zafar et al., 2012). Somatostatin (SST) is a particularly attractive treatment candidate for TLE (Brazeau et al., 1973; Epelbaum, 1986; Tallent and Qiu, 2008; Vezzani and Hoyer, 1999). The 116 amino acid preprohormone preproSST is cleaved by proteases into biologically active SST-14, SST-28 and neuronostatin neuropeptides (Billova et al., 2007; Galanopoulou et al., 1995; Goodman et al., 1983; Samson et al., 2008; Tavianini et al., 1984; Winsky-Sommerer et al., 2000).
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2023, International Journal of Molecular SciencesOlfactory placode generates a diverse population of neurons expressing GnRH, somatostatin mRNA, neuropeptide Y, or calbindin in the chick forebrain
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