At the cutting edgePLC-α: A common mediator of the action of estrogen and other hormones?
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Regulation of cocaine-related behaviours by estrogen and progesterone
2022, Neuroscience and Biobehavioral ReviewsCitation Excerpt :One mechanism of regulation of cellular function by ERs is initiation of intracellular signalling cascades. E2 activates phospholipase C (PLC)/protein kinase C (PKC) (Mobbs et al., 1991), mitogen-activated protein kinase (MAPK) (Singh et al., 1999), cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) (Aronica et al., 1994; Balthazart, 2021), and phosphatydilinositol 3 kinase (PI3K) (Etgen et al., 2006) intracellular signalling cascades within seconds or minutes [see (Kokane and Perrotti, 2020) for a discussion of these pathways in the context of E2-potentiated responsivity to drugs]. E2 or the membrane-impermeable E2-bovine serum albumin (BSA) conjugate increased baseline MAPK-dependent phosphorylation of cAMP response element (CRE)-binding protein (CREB) and inhibited K-induced pCREB in cultured female rat hippocampal neurons, indicating that central E2-induced intracellular signalling is initiated at the plasma membrane (Boulware et al., 2005).
Estrogen Regulation of Neurotransmitter and Growth Factor Signaling in the Brain
2017, Hormones, Brain and Behavior: Third EditionImportance of sex to pain and its amelioration; relevance of spinal estrogens and its membrane receptors
2012, Frontiers in NeuroendocrinologyCitation Excerpt :In fact, caveolins are essential for many membrane ERα responses (Luoma et al., 2008), e.g., functional coupling of ERα to mGluR1 (Boulware et al., 2007). Stimulation of plasma membrane ERs is coupled to the activation of the same spectrum of signaling molecules that participate in most membrane initiated signaling cascades, e.g., protein kinase A, protein kinase B, protein kinase C, phospholipase C, inositol trisphosphate, MAPK, ERK, tyrosine kinases, etc. (Aronica et al., 1994; Bi et al., 2000; Cardona-Gomez et al., 2002; Gu and Moss, 1996; Lieberherr et al., 1993; Marino et al., 1998; Mendoza et al., 1995; Minami et al., 1990; Mobbs et al., 1991; Nabekura et al., 1986; Qiu et al., 2003; Razandi et al., 1999; Singh et al., 1999; Szego and Davis, 1967; Toran-Allerand et al., 1999; Watters et al., 1997; Zhou et al., 1996). Estrogens can also modulate neuronal membrane excitability by gating calcium currents (Bologa et al., 2006; Chaban et al., 2003; Improta-Brears et al., 1999; Lee et al., 2002; Mermelstein et al., 1996; Morley et al., 1992; Revankar et al., 2005).
Estrogen regulation of neurotransmitter and growth factor signaling in the brain
2009, Hormones, Brain and Behavior Online