Elsevier

Neuroscience Letters

Volume 66, Issue 3, 23 May 1986, Pages 287-292
Neuroscience Letters

Possible involvement of the S-adenosyl-l-homocysteine metabolites, adenosine and l-homocysteine, in sleep in rats

https://doi.org/10.1016/0304-3940(86)90033-9Get rights and content

Abstract

The effects of i.p. injections of adenosine (Ado) and homocysteine at 17.00 h were tested on the rat sleep-waking cycle. Administration of 7 and 50 mg/kg of Ado resulted in a significant increase in sleep in otherwise saline male rats during the environmental-dark period (18.00–06.00 h). Increments of paradoxical sleep were maximal with the smaller dose of Ado. The larger dose increased slow-wave sleep during the first 2 h. In contrast, administration of homocysteine (7 mg/kg) had no effect while a larger dose (50 mg/kg) induced a slight but significant long-lasting decrease of paradoxical sleep. These results were compared with those previously obtained with S-adenosyl-l-homocysteine (SAH), an intracellular precursor of Ado and l-homocysteine. It is proposed that the reported hypnotic action of exogenous SAH in rats could be mediated by Ado receptors.

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