Elsevier

Neuroscience Letters

Volume 65, Issue 1, 28 March 1986, Pages 65-71
Neuroscience Letters

The role of specific ions in glutamate neurotoxicity

https://doi.org/10.1016/0304-3940(86)90121-7Get rights and content

Abstract

When the chick embryo retina is incubated in balanced salt solution containing glutamate (Glu) in 1 mM concentration, a neurodegenerative reaction occurs within 30 min. Here we report that the neurotoxic action of Glu on retinal neurons is dependent on the presence of Na+ and Cl, but not Ca2+, in the incubation medium. Also, we report that depolarizing concentrations of K+ can induce a severe cytotoxic reaction in chick retina which, like the depolarization-linked neurotoxicity of Glu, is a Cl-dependent phenomenon.

References (30)

  • D. Acosta et al.

    Role of calcium in cytotoxic injury of cultured hepatocytes

    Ann. N. Y. Acad. Sci.

    (1983)
  • E. Berdichevsky et al.

    Kainate, N-methylaspartate and other excitatory amino acids increase calcium influx into rat brain cortex cells in vitro

    Neurosci. Lett.

    (1983)
  • D.W. Choi

    Glutamate neurotoxicity in cortical cell culture is calcium-dependent

    Neurosci. Lett.

    (1985)
  • J.T. Coyle

    Neurotoxic action of kainic acid

    J. Neurochem.

    (1983)
  • R. Dingledine

    N-methylaspartate activates voltage-dependent calcium conductance in rat hippocampal pyramidal cell

    J. Physiol. (London)

    (1983)
  • R.H. Evans et al.

    Selective antagonism by Mg2+ of amino acid-induced depolarization of spinal neurones

    Experienta

    (1977)
  • M.W. Fariss et al.

    Vitamin E reversal of the effect of extracellular calcium on chemically induced toxicity in hepatocytes

    Science

    (1985)
  • A.C. Foster et al.

    Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid

    Neurosci. Lett.

    (1984)
  • G. Jancsó et al.

    Neurotoxin induced nerve cell degeneration: possible involvement of calcium

    Brain Res.

    (1984)
  • J.F. MacDonald

    Substitution of extracellular sodium ions blocks the voltage-dependent decrease of input conductance evoked by L-aspartate

    Can. J. Physiol. Pharmacol.

    (1984)
  • R.F. Miller et al.

    Excitatory amino acid receptors in the vertebrate retina

  • J.W. Olney

    Glutamate-induced neuronal necrosis in the infant mouse hypothalamus

    An electron microscopic study

    J. Neuropathol. Exp. Neurol.

    (1971)
  • J.W. Olney

    Neurotoxicity of excitatory amino acids

  • J.W. Olney

    Glutamate-induced retinal degeneration in neonatal mice

    Electron microscopy of the acutely evolving lesion

    J. Neuropathol. Exp. Neurol.

    (1969)
  • Olney, J.W., Collins, R.C. and Sloviter, R.S., Excitotoxic mechanisms of epileptic brain damage. In A.V....
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