Elsevier

Neuroscience Letters

Volume 110, Issue 3, 14 March 1990, Pages 319-324
Neuroscience Letters

β-Amyloid protein promotes neuritic branching in hippocampal cultures

https://doi.org/10.1016/0304-3940(90)90867-9Get rights and content

Abstract

In the neuritic plaques of Alzheimer's disease, abnormal neuritic processes cluster around a core of β-amyloid protein. Previous data have shown that β1–28, a peptide homologous to the first 28 amino acid residues of β-amyloid protein, enhanced survival without affecting neuritic extension or branching in cultures of hippocampal neurons. In this paper we show that β1–42, a synthetic peptide which corresponds to the full 42 amino acid sequence of β-amyloid protein, increased cell survival and also promoted the elongation of axon-like processes, raised the number of dendrite-like processes, and increased their arborization.

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