Cyclic AMP induces long-term increase in synaptic efficacy in CA1 region of rat hippocampus
References (12)
- et al.
The action of norepinephrine in the dentate gyrus: beta-mediated facilitation of evoked potentials in vitro
Brain Res.
(1985) - et al.
Noradrenergic responses in rat hippocampus: evidence for mediation by α and β receptors in the in vitro slice
Brain Res.
(1981) The action of norepinephrine in the rat hippocampus: intracellular studies on the slice preparation
Brain Res.
(1981)- et al.
The effect of high-frequency stimulation and norepinephrine on cyclic AMP levels in normal versus norepinephrine depleted rat hippocampal slices
Brain Res.
(1985) - et al.
Long-term potentiation of synaptic transmission in the hippocampus: properties and mechanisms
- et al.
Tetanic stimulation causes an APV-sensitive increase in cAMP levels in rat hippocampal CA1 region
Soc. Neurosci. Abstr.
(1990)
Cited by (33)
The role of phosphodiesterases in hippocampal synaptic plasticity
2013, NeuropharmacologyCitation Excerpt :cAMP dependent protein kinase (PKA) is a powerful signalling molecule activated by cAMP (Beavo et al., 1974; Miyamoto et al., 1969; Reimann et al., 1971; Walsh et al., 1968) and many of the effects of cAMP in synaptic plasticity discovered to date are thought to be mediated by this kinase. At a simple level enhanced synaptic transmission as a result of cAMP signalling has been shown to be possible in hippocampal slices as this can be induced by application of the AC activator forskolin or the cAMP analogue Sp-cAMPS (Chavez-Noriega and Stevens, 1992; Huang and Kandel, 1994; Pockett et al., 1993; Slack and Pockett, 1991) and these effects are blocked by PKA antagonists (Trudeau et al., 1996; Woo et al., 2002). During experimentally induced LTP, production of cAMP can be induced by specific isoforms of AC that are activated by Ca2+/calmodulin (AC1 and AC8) as a result of calcium entry through NMDA receptors (Chetkovich et al., 1991; Chetkovich and Sweatt, 1993; Collingridge et al., 1983; Eliot et al., 1989), and this has been shown to be relevant to LTP and behaviour as mice that lack these isoforms of AC have impairments in hippocampal dependent forms of memory as well as in LTP (Wong et al., 1999).
Post-training intrahippocampal infusion of nicotine-bucladesine combination causes a synergistic enhancement effect on spatial memory retention in rats
2007, European Journal of PharmacologyRegulation of hippocampal synaptic plasticity by cyclic AMP-dependent protein kinases
2003, Progress in NeurobiologyTetanic stimulation and metabotropic glutamate receptor agonists modify synaptic responses and protein kinase activity in rat auditory cortex
2001, Brain ResearchCitation Excerpt :However, PKC antagonists block both PKC and PKA, suggesting that tetanus-induced potentiation in the auditory cortex may be a result of PKC activation, PKA activation, or some combination of both. Indeed, in the amygdala, hippocampus and cerebellum PKA appears to be involved in regulation of synaptic strength [14,26,34,38,39,89,94]. It is unknown, but would be of interest to determine if PKA inhibitors also block potentiation in auditory cortex, as this would aid in revealing the causal link between the potentiation and PKC and PKA.