Elsevier

Neuroscience Letters

Volume 128, Issue 1, 8 July 1991, Pages 81-84
Neuroscience Letters

Demonstration of neurofibrillary tangles in parvalbumin-immunoreactive interneurones in the cerebral cortex of Alzheimer-type dementia brain

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Abstract

The pathological changes occurring in a population of parvalbumin-like immunoreactive cerebral cortical interneurones in postmortem Alzheimer-type dementia brain tissue were determined by double staining cerebral cortical sections for parvalbumin, tau and/or calpain-like immunoreactivities. By counting the number of double immunostained cells it was determined that 4% parvalbumin and 25% of calpain-like immunoreactive cells showed evidence of tau-like immunoreactivity, indicative of neurofibrillary tangles. These results suggest that cerebral cortical parvalbumin-like immunoreactive neurones are relatively resistant to the pathological changes underlying the formation of neurofibrillary tangles associated with Alzheimer-type dementia.

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    Interneurons seem to be very resistant, perhaps because of their high content of calcium-binding proteins such as parvalbumin or calretinin (Braak et al., 1991; Nitsch and Ohm, 1995; Freund and Buzsaki, 1996). However, an obligatory absence cannot be presumed because in frontal cortex 4–6% parvalbumin-containing neurons also reacted with an antibody raised against tau from tangles (Iwamoto and Emson, 1991). Others have reported only a 0–0.7% subpopulation of parvalbumin-containing neurons of the superior frontal gyrus which may have tangles (Sampson et al., 1997).

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