Met-enkephalin immunoreactivity in the basal ganglia in symptomatic and asymptomatic MPTP-exposed monkeys: correlation with degree of parkinsonian symptoms
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The globus pallidus as a target for neuropeptides and endocannabinoids participating in central activities
2020, PeptidesCitation Excerpt :Similarly low levels of enkephalin and met-enkephalin are observed in the globus pallidus of marmosets prenatally treated with MPTP [83] and in MPTP mice [84]. In addition to low levels of enkephalin and/or met-enkephalin in the globus pallidus in parkinsonian states, other studies have shown increased levels of enkephalin in the globus pallidus [85–88]. Bourdenx et al. [88] reported that the levels of met-enkephalin, C-terminally extended met-enkephalin and leu-enkephalin are increased in MPTP parkinsonian monkeys, and levodopa treatment induces a strong decrease in the expression of met-enkephalin and leu-enkephalin.
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