Determination of basal acetylcholine release in vivo by rat brain dialysis with a U-shaped cannula: effect of SM-10888, a putative therapeutic drug for Alzheimer's disease
References (13)
- et al.
Brain dialysis: detection of acetylcholine in the striatum of unrestrained and unanesthetized rats
Neurosci. Lett.
(1987) - et al.
Modulation of acetylcholine release by D1, D2 dopamine receptors in rat striatum under freely moving conditions
Brain Res.
(1990) - et al.
The effect of acetylcholinesterase inhibition on the release of acetylcholine from the striatum in vivo: interaction with autoreceptor responses
Neurosci. Lett.
(1990) - et al.
Determination of acetylcholine and choline in perchlorate extracts of brain tissue using liquid chromatography - electrochemistry with an immobilized reactor
J. Chromatogr.
(1987) - et al.
Stimulation of the nucleus basalis of Meynert increases acetylcholine release in the cerebral cortex in rats
Neurosci. Lett.
(1989) - et al.
Effect of unilateral nucleus basalis lesion on cortical and striatal acetylcholine and dopamine release monitored in vivo with microdialysis
Neurosci. Lett.
(1990)
Cited by (24)
Analysis of acetylcholine from extracellular fluid in brain by in vivo microdialysis and LC-ESI-MS/MS with the stable isotope-labeled internal standard
2011, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesCitation Excerpt :It is generally not used as an administered drug, due to the rapid degradation by cholinesterase, but it is useful in some ophthalmological applications. It is important to determine the concentration of ACh in the extracellular fluid of the brain, to reveal changes related to Alzheimer's and Parkinson's disease [1–6]. The concentration of ACh in the extracellular fluid is relatively reliable for the evaluation of a particular neuronal activity, and could be utilized in the research on the illness mechanisms, and development of medicines for these diseases.
Quantitative analysis of acetylcholine in rat brain microdialysates by liquid chromatography coupled with electrospray ionization tandem mass spectrometry
2010, Journal of Neuroscience MethodsCitation Excerpt :In the CNS, ACh plays a major role in functions of memory and learning, attention, temperature control, blood pressure and sleep regulation (Wessler et al., 1998; Boonyapisit et al., 1999; Testa et al., 1996; Sarter and Bruno, 1998; Ikawa et al., 1980). Deficits in central cholinergic system are a well-known characteristic of poor cognitive performance associated with Alzheimer's disease, schizophrenia and Parkinson's disease (Davies et al., 1977; Coyle et al., 1983; Beatty et al., 1986; Xu et al., 1991; White and Cummings, 1996; Felician and Sandson, 1999). In order to provide valuable information for understanding involvement of central cholinergic transmission in disease pathology/etiology it is important to detect and monitor levels of ACh in brain extracellular fluid.
Development of a liquid chromatography/tandem mass spectrometry method for the quantitation of acetylcholine and related neurotransmitters in brain microdialysis samples
2007, Journal of Pharmaceutical and Biomedical AnalysisMeasurement of neurotransmitters from extracellular fluid in brain by in vivo microdialysis and chromatography-mass spectrometry
2006, Journal of Pharmaceutical and Biomedical AnalysisChapter 3.1 Liquid chromatographic methods used for microdialysis: an overview
2006, Handbook of Behavioral NeuroscienceCitation Excerpt :This problem can partially be overcome by using an internal standard such as butyrylcholine (Kehr et al., 1998). Using the Pt-electrode, LOD's of 2 nM at best (Xu et al., 1991: Greaney et al., 1993; Carter and Kehr, 1997) have been achieved. In most cases, this sensitivity was not sufficient to be able to detect baseline release of Ach from microdialysates, so that an acetylcholine esterase inhibitor such as neostigmine or physostigmine needed to be added to the perfusion fluid for adequate quantification.