Hippocampal kindling leads to different changes in paired-pulse depression of local evoked field potentials in CA1 area and in fascia dentata

doi:10.1016/0304-3940(92)90344-7

Neuroscience Letters

Volume 141, Issue 1, 6 July 1992, Pages 101-105

https://doi.org/10.1016/0304-3940(92)90344-7 Get rights and content

Abstract

Monosynaptic evoked field potentials (EPs) in response to paired-pulse stimulation (20 ms interval) were recorded in area CA1 and fascial dentata of the same animal in the course of development of a kindled focus in the CA1 region. A significant reduction of paired pulse depression in response to medium and high stimulation intensity was found in CA1. A similar change was found in the fascia dentata in response to medium intensity stimulation of the angular bundle. In contrast, at high intensity, paired pulse depression was enhanced in the fascia dentata in the course of kindling. These results indicate that kindling epileptogenesis is accompanied by regionally different changes in recurrent inhibition: a reduction in CA1 and intensity dependent changes in fascia dentata.

References (27)

M. De Jonge et al.
The development and decay of kindling-induced increases in paired-pulse depression in the dentate gyrus
Brain Res.
(1987)
P.-W. Gean et al.
Spontaneous epileptiform activity and alteration of GABA- and of NMDA-mediated neurotransmission in amygdala neurons kindled in vivo
Brain Res.
(1989)
G.V. Goddard et al.
A permanent change in brain function resulting from daily electrical stimulation
Exp. Neurol.
(1969)
J.A. Gorter et al.
Paradoxical sleep deprivation does not affect neuronal excitability in the rat hippocampus
Brain Res.
(1989)
T.D. Hernandez et al.
Long-term changes in sensitivity to GABA in dorsal raphe neurons following amygdala kindling
Brain Res.
(1990)
W. Kamphuis et al.
Changes in local evoked potentials in the rat hippocampus (CA1) during kindling epileptogenesis
Brain Res.
(1988)
W. Kamphuis et al.
Long-term decreased sensitivity of hippocampal pyramidal cells to GABA induced by kindling epileptogenesis
Neuroscience
(1991)
J. Kapur et al.
Evidence for a chronic loss of inhibition in the hippocampus after kindling: electrophysiological studies
Epilepsy Res.
(1989)
W. Löscher et al.
Further evidence for abnormal GABAergic circuits in amygdala-kindled rats
Brain Res.
(1987)
E. Maru et al.
Alteration in dentate neuronal activities associated with perforant path kindling. III Enhancement of synaptic inhibition
Exp. Neurol.
(1987)

H.B. Michelson et al.

Reduction of paired-pulse inhibition in the CA1 region of the hippocampus by pilocarpine in naive and amygdala-kindled rats

Exp. Neurol.

(1989)

J.N. Nobrega et al.

Autoradiographic analysis of benzodiazepine binding in entorhinal kindled rat brains

Brain Res.

(1989)

J.N. Nobrega et al.

Regional brain [³H]muscimol binding in the kindled rat brain: a quantitative autoradiographic examination

Epilepsy Res.

(1990)

Cited by (0)

View full text