The GABAA receptor complex in experimental absence seizures in rat: An autoradiographic study
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Cited by (24)
Upholding WAG/Rij rats as a model of absence epileptogenesis: Hidden mechanisms and a new theory on seizure development
2016, Neuroscience and Biobehavioral ReviewsCitation Excerpt :GABA-mediated mechanisms have been extensively studied within the CTC system, and there is evidence that both GABAA and GABAB receptors are involved in the generation of SWDs (Snead, 1995; van Luijtelaar and Sitnikova, 2006). GABAergic neurons in the NRT and their projections to the specific relay nuclei of the thalamus are involved in the development/regulation of absence seizures (Hosford et al., 1997; Snead, 1992; Snead et al., 1992). Interestingly, it has been suggested that the balance between GABAA(Cl−) and GABAB(K+)-mediated conductances is essential for the control of SWDs (Kaminski et al., 2001; Marescaux et al., 1992b; Vergnes et al., 1984).
Autoradiographic imaging and quantification of the high-affinity GHB binding sites in rodent brain using <sup>3</sup>H-HOCPCA
2016, Neurochemistry InternationalCitation Excerpt :The absolute Bmax values found for GHB high-affinity binding sites by us and others are exceptionally high, which instantly questions their biological identity and importance. For comparison, Bmax values for GABAA receptors as measured with 3H-muscimol in autoradiography are approximately two orders of magnitude lower (Snead et al., 1992). The Kd value for 3H-HOCPCA was found to be 9–10 times numerically lower than for 3H-NCS-382, confirming previously reported data (Wellendorph et al., 2005; Vogensen et al., 2013).
Morphometric changes and molecular mechanisms in rat models of idiopathic generalized epilepsy with absence seizures
2011, Neuroscience LettersCitation Excerpt :WAG/Rij rats are typically compared with outbred Wistar rats but, as they are not derived from the same original colony, molecular and morphometric differences identified between these strains do not have the same a priori likelihood to be specifically associated with the epilepsy phenotype as for differences between GAERS and NEC rats. Research from many laboratories around the world has established that both the GAERS and the WAG/Rij are excellent models of human IGE with absence seizures because of the similarities in seizure, behavioural, electrophysiological, pathophysiological and pharmacological profiles to those of human IGE with absence epilepsy (reviewed by [18,22,70]). Recordings with intracerebral electrodes have shown that the seizure discharges are generated within the thalamocortical circuitry, without involving the hippocampus [92], as is believed to be the case with human absence seizures [33,97].
Genetic Models of Absence Epilepsy in the Rat
2006, Models of Seizures and EpilepsyThalamic, Thalamocortical, and Corticocortical Models of Epilepsy with an Emphasis on Absence Seizures
2006, Models of Seizures and Epilepsy