Seizure-like activity disrupts LTP in vitro
References (15)
Electroconvulsive Therapy
(1992)- et al.
Electroconvulsive treatment reduces long-term potentiation in rat hippocampus
Brain Res.
(1987) - et al.
Long-lasting potentiation of synaptic transmission in the dentate area of the anesthetized rabbit following stimulation of the perforant path
J. Physiol.
(1973) - et al.
Low-frequency activation of the NMDA receptor system can prevent the induction of LTP
Neurosci. Lett.
(1989) - et al.
NMDA receptors — their role in long-term potentiation
Trends Neurosci.
(1987) - et al.
The NMDA receptor antagonist d-2-amino-5-phosphonopentanoate (d-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro
J. Neurosci.
(1992) - et al.
Reversible loss of hippocampal long term potentiation following electroconvulsive seizures
Nature
(1976)
Cited by (30)
Time-dependent changes in learning ability and induction of long-term potentiation in the lithium-pilocarpine-induced epileptic mouse model
2010, Epilepsy and BehaviorCitation Excerpt :However, the neurophysiological basis for the learning deficits in patients with epilepsy and animal models has not yet been established. Because long-term potentiation (LTP), a form of synaptic plasticity that is considered a physiological model of mammalian memory formation [11], is markedly impaired or even erased in hippocampal neurons in both humans with epilepsy and animal models of epilepsy [12–17], the abolishment of LTP has been considered an important cellular mechanism underlying learning deficits in epilepsy [18,19]. Several reports, however, have also proposed that the development of epileptic foci is similar to that of LTP [20–24].
Neuregulin blocks synaptic strengthening after epileptiform activity in the rat hippocampus
2008, Brain ResearchCitation Excerpt :When measured at 50 min after high K+ washout, slices treated with NRG1β showed substantially less potentiation than control slices (control: 151 ± 15% potentiation, n = 9; NRG1β-treated: 102 ± 6% potentiation, n = 5, p < 0.01, Student's t-test on independent samples). Seizure-like activity can disrupt the induction of long term potentiation in both in vivo seizure models (Hesse and Teyler 1976; Anwyl et al., 1987) and in vitro slice models (Moore et al., 1993; Barr et al., 1997). Disruption of LTP after seizures may underlie memory impairment that results from seizures.
Kainate-induced epileptic seizures induce a recruitment of caldendrin to the postsynaptic density in rat brain
2003, Molecular Brain ResearchProgressive cognitive decline in epilepsy: An indication of ongoing plasticity
2002, Progress in Brain Research