Elsevier

Neuroscience Letters

Volume 149, Issue 2, 12 January 1993, Pages 133-136
Neuroscience Letters

Properties of single Na+-activated K+ channels in cultured central neurons of the chick embryo

https://doi.org/10.1016/0304-3940(93)90754-9Get rights and content

Abstract

Na+-activated K+ channels (IK[Na]) of cultured chick brainstem neurons do not run down following excision of inside-out patches, but this occurs within seconds to minutes in cultured chick olfactory bulb neurons. IK[Na] channels of chick brainstem neurons exhibit a main conductance state of 95–105 pS, and also express multiple sub-conductance states. These channels have complex kinetics, with multiple closed and main conductance states. The average lifetime of the main conductance state is not dependent on the Na+ concentration used to activate the channels.

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