Differential effects of ethanol on the firing rates of Golgi-like neurons and Purkinje neurons in cerebellar slices in vitro
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Cited by (20)
Ethanol enhances both action potential-dependent and action potential-independent GABAergic transmission onto cerebellar Purkinje cells
2009, NeuropharmacologyCitation Excerpt :Therefore, the discrepancy between our results and theirs could have arisen from differences between sample preparations and/or between rodent species. EtOH-induced enhancement of the tonic inhibition of granule cells has been considered to be one of the possible reasons for the alcohol-induced impairment of motor coordination (Freund et al., 1993; Carta et al., 2004; Hanchar et al., 2005). Carta et al. (2004) reported that 50 mM EtOH only increases the firing rate of Golgi cells in the granular layer, whereas 100 mM EtOH can additionally enhance the action potential-independent GABAergic transmission between Golgi cells and granule cells in the rat cerebellum.
Modulation of GABA<inf>A</inf> receptors in cerebellar granule neurons by ethanol: a review of genetic and electrophysiological studies
2007, AlcoholCitation Excerpt :Single unit recordings showed that intraperitoneal injection of EtOH increases the discharge rate of rat inferior olivary nucleus neurons (Rogers et al., 1986). Acute EtOH exposure was shown to increase firing of inhibitory Golgi interneurons in cerebellar slices (Freund et al., 1993b). The authors of this study stated that this effect would be predicted to increase Golgi neuron input to CGNs and ultimately influence excitatory input to Purkinje neurons.
Effect of chronic ethanol ingestion on Purkinje and Golgi cell firing in vivo and on motor coordination in mice
2005, Brain ResearchCitation Excerpt :Moreover, their firing also reflects the excitation of the cerebellar cortex by mossy fibers, since mossy fibers excite granule cells that in turn excite Golgi cells through the same type of AMPA receptors as Purkinje cells. However, only one study has to our knowledge been conducted on the effects of ethanol on Golgi cells, demonstrating the excitatory effect of ethanol on these neurons in slice preparation [20]. To better understand the effects of chronic ethanol on cerebellar cortex function, we studied motor coordination and spontaneous Purkinje and Golgi cell firing in non-anesthetized mice after a 3-month period of ethanol consumption.
Ethanol effects on temperature-sensitive hypothalamic neurons in rat brain slices
2004, Journal of Thermal BiologyThe contribution of electrophysiology to knowledge of the acute and chronic effects of ethanol
1999, Pharmacology and Therapeutics