Nuclear factor-κB in rat brain: Enhanced DNA-binding activity following convulsant-induced seizures
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Up-regulated BAFF and BAFF receptor expression in patients with intractable temporal lobe epilepsy and a pilocarpine-induced epilepsy rat model
2017, SeizureCitation Excerpt :The NF-κB pathway plays key roles in the regulation of immune and inflammatory responses, including regulating the activity of many cytokines, chemokines, and immunoreceptors [39,40]. Additionally, NF-κB has been implicated in the neuropathological processes of seizures and epilepsy and is essential for a number of physiological CNS functions [41]. Some studies have illustrated that NF-κB is involved in seizure susceptibility, and inhibiting NF-κB activation could enhance the efficacy of AEDs [42].
Repeated exposure to low doses of kainic acid activates nuclear factor kappa B (NF-κB) prior to seizure in transgenic NF-κB/EGFP reporter mice
2014, NeuroToxicologyCitation Excerpt :Rapid induction of IEGs results from activation of primary stress pathways including the NF-κB pathway (Baeuerle, 1991). Indeed, activation of NF-κB has been observed in response to a number of stimuli such as increased neuronal activity and chemically and electrically induced seizures (Prasad et al., 1994; Rong and Baudry, 1996). A significant amount of NF-κB in neurons resides at the level of the synapse conferring a direct link from synapse to nucleus for rapid induction of gene expression upon synaptic stimulation (Kaltschmidt et al., 1993).
The effects of dexamethasone on rat brain cortical nuclear factor kappa B (NF-κB) in endotoxic shock
2006, Toxicology and Applied PharmacologySignal transduction and neurosurvival in experimental models of brain injury
2003, Brain Research Bulletin