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2021, Neurobiology of StressSynthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - Neurokinin-1 antagonist peptidomimetics
2015, European Journal of Medicinal ChemistryCitation Excerpt :When opioid ligands are administered for a longer period of time, side effects such as, for example, constipation, physical dependence and analgesic tolerance emerge [1]. Moreover, opioids have less analgesic efficacy in neuropathic pain, a pathology which is considered to be a major healthcare burden [2–6]. Neuropathic pain can be caused by a damaged nerve in the nervous system, be the result of trauma, an infection, or diabetes [7], and it is characterized by an increased sensitivity to non-noxious and noxious stimuli [8,9].
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