State-dependent changes of extracellular glutamate in the medial preoptic area in freely behaving rats
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The importance of ligand gated ion channels in sleep and sleep disorders
2023, Biochemical PharmacologyLocal administration of bicuculline into the ventrolateral and medial preoptic nuclei modifies sleep and maternal behavior in lactating rats.
2021, Physiology and BehaviorCitation Excerpt :In agreement with our present data, Chari et al. (1995) found no impact on sleep after local delivery of GABA into the mPOA [57]. Nevertheless, the role of the mPOA in the regulation of sleep has been demonstrated using different techniques [10, 16, 58-64]. However, since the protocol and doses applied for the mPOA were the same as in the VLPO, the results suggest that the GABAergic processes that control sleep in the postpartum rat are weaker within the mPOA than in the VLPO.
Glutamate Activates the Histaminergic Tuberomammillary Nucleus and Increases Wakefulness in Rats
2019, NeuroscienceCitation Excerpt :Dash MB et al. showed that the concentration of glutamate in prefrontal and motor cortex increased progressively during waking and REM sleep and decreased in NREM sleep (Dash et al., 2009). Otherwise, the extracellular level of glutamate in the pedunculopontine tegmental nucleus (Kodama and Honda, 1999), the medial preoptic area (Azuma et al., 1996), and the nucleus accumbens (Lena et al., 2005) was reported to be increased during wakefulness and decreased during NREM or REM sleep. Astrocytes also play a vital role in sleep wake regulation.
Glutamate microinjection at the medial preoptic area enhances slow wave sleep in rats
2011, Behavioural Brain ResearchEffects of the fatty acid amide hydrolase inhibitor URB597 on the sleep-wake cycle, c-Fos expression and dopamine levels of the rat
2007, European Journal of PharmacologyModulation of glutamate-induced outward current by prostaglandin E <inf>2</inf> in rat dissociated preoptic neurons
2005, Brain ResearchCitation Excerpt :Glutamate is a major excitatory neurotransmitter in the hypothalamus including the POA. Activation of glutamate receptors (GluRs) in the POA has been reported to modulate various physiological functions including neuroendocrine, reproduction, body temperature, and vigilance state [3,5,39]. There is compelling evidence that proinflammatory cytokines and related mediators are involved in the GluR-mediated physiological and pathological processes [1,7,8,21,28,33,35], although underlying mechanisms are not very clear.
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The authors are grateful to Professor Takeo Machida, Saitama University, Japan for his encouragement.