Zinc · protoporphyrin is a selective inhibitor of heme oxygenase activity in the neonatal rat
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Theoretical (DFT) study on the hydroxylation mechanism of Sn(IV)porphyrin: How does Sn(IV)porphyrin inhibit heme oxygenase catalysis function
2022, Journal of Molecular StructureCitation Excerpt :Metalloporphyrins (MPs) known as competitive inhibitors of HO control hyperbilirubinemia via preventation of excessive bilirubin formation [25]. These compounds are heme anlogoues with zinc, tin, and manganese as the central metal ions, and have higher binding affinity than heme to HOs [26,27]. It's supposed that metalloporphyrins by blocking the active site of HO inhibit heme degradation, however, the mechanism of inhibition process has not been obviously understood.
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2015, Life SciencesCitation Excerpt :ZnPP pre-treatment group (ZnPP + OALT group), 32 mg/kg zinc protoporphyrin (ZnPP) (Frontier Scientific, Carnforth, Lancashire, UK) was intraperitoneally administrated 24 h before the operation. ZnPP, a competitive inhibitor of HO-1, is an endogenously molecule formed during heme biosynthesis [24], and its level often increases in chronic anemia disorders [14,15]. The time point was chosen based on the results of a previous study showing peak expression of HO-1 at 24 h after the administration of hemin [34].
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2014, Chemico-Biological InteractionsCitation Excerpt :Animals were sacrificed 12 h later. ZnPP (40 μmole/kg body weight) was injected subcutaneously twice a day for 2 days (4 doses) [19]. Indomethacin or vehicle was administered orally along with the third dose of ZnPP and animals were sacrificed 24 h after the indomethacin/vehicle dose.