Elsevier

Neuroscience

Volume 22, Issue 2, August 1987, Pages 499-524
Neuroscience

Neurotensin in the human brain

https://doi.org/10.1016/0306-4522(87)90349-6Get rights and content

Abstract

The localization of neurotensin-immunoreactive sites in the adult human brain was investigated by the indirect immunoperoxidase method of Sternberger [Sternberger (1979) Immunocytochemistry. Wiley, New York]. Our results demonstrate a widespread, albeit uneven occurrence of neurotensin-immunoreactive cells and processes throughout the central nervous system. Immunoreactive cells are prominent in the medial hypothalamus and in various regions of the limbic system, including the amygdaloid body, septal area, bed nucleus of the stria terminalis and piriform cortex. A few cells were also found in the dorsal synencephalon, superior colliculus, periaqueductal grey and spinal trigeminal nucleus.

The distribution of immunoreactive fibres corresponds well with that reported for rodents. Areas with the highest concentration of neurotensin-immunoreactive processes included all the areas where immunoreactive neurons were found and, in addition, periventricular thalamic nuclei, the sublenticular region, lateral parts of the brainstem reticular formation and the vagus-solitarius complex. Comparison mapping studies of melanin-containing neurons on sections treated with neurotensin antiserum revealed an anatomical relation between almost all the catecholaminergic cell clusters with peptide-containing fibres.

Reference (99)

  • KalivasP.W. et al.

    Behavioral and neurochemical effects of neurotensin microinjection into the ventral tegmental area of the rat

    Neuroscience

    (1983)
  • KalivasP.W. et al.

    Increase in spontaneous motor activity following infusion of neurotensin into the ventral tegmental area

    Brain Res.

    (1981)
  • KataokaK. et al.

    Regional distribution of immunoreactive neurotensin in monkey brain

    Brain Res. Bull.

    (1979)
  • KöhlerC. et al.

    Autoradiographic localization of [3H]neurotensin-binding sites in the hippocampal region of the rat and primate brain

    Neuroscience

    (1985)
  • LangevinH. et al.

    Distribution of substance P, somatostatin and neurotensin in the human hypothalamus

    Brain Res.

    (1982)
  • LazarusL.H. et al.

    Distribution, localization and characteristics of neurotensin binding sites in the rat brain

    Neuropharmacology

    (1977)
  • LeemanS.E. et al.

    Substance P and neurotensin

    Rec. Prog. Horm. Res.

    (1982)
  • McDermottJ.R. et al.

    Mechanism of degradation of LH-RH and neurotensin by synaptosomal peptidases

    Peptides

    (1983)
  • MaedaK. et al.

    Neurotensin release by rat hypothalamic fragments in vitro

    Brain Res.

    (1981)
  • MaiJ.K. et al.

    Substance P in the human brain

    Neuroscience

    (1986)
  • MartinG.E. et al.

    Antinociceptive and hypothermic actions of neurotensin administered centrally in the rat

    Neuropeptides

    (1981)
  • NemeroffC.B. et al.

    Neurotensin: central nervous system effects of a hypothalamic peptide

    Brain Res.

    (1977)
  • NemeroffC.B. et al.

    Neurotensin-dopamine interactions in the CNS

    Trends pharmac. Sci.

    (1985)
  • NemeroffC.B. et al.

    Neurotensin: central nervous system effects of a neuropeptide

    Trends Neurosci.

    (1980)
  • NinkovicM. et al.

    Effect of dorsal rhizotomy on the autoradiographic distribution of opiate and neurotensin receptors and neurotensin-like immunoreactivity within the rat spinal cord

    Brain Res.

    (1981)
  • PearsonJ. et al.

    Human brainstem catecholamine neuronal anatomy as indicated by immunocytochemistry with antibodies to tyrosine hydroxylase

    Neuroscience

    (1983)
  • QuirionR.

    Interactions between neurotensin and dopamine in the brain: an overview

    Peptides

    (1983)
  • RechesA. et al.

    Neurotensin interacts with dopaminergic neurons in rat brain

    Peptides

    (1983)
  • SarrieauA. et al.

    Characterization and autoradiographic distribution of neurotensin binding sites in the human brain

    Brain Res.

    (1985)
  • StanzioneP. et al.

    Action of neurotensin on spinal cord neurons in the rat

    Brain Res.

    (1983)
  • UhlG.R. et al.

    Regional and subcellular distribution of brain neurotensin

    Life Sci.

    (1976)
  • UhlG.R. et al.

    Neurotensin receptor binding, regional and subcellular distributions favour transmitter role

    Eur. J. Pharmac.

    (1977)
  • UhlG.R. et al.

    Parkinson's disease: depletion of substantia nigra neurotensin receptors

    Brain Res.

    (1984)
  • YoungW.S. et al.

    Neurotensin receptor localization by light microscopic autoradiography in rat brain

    Brain Res.

    (1981)
  • AlvordE.C. et al.

    The pathology of Parkinsonism: a comparison of degenerations in cerebral cortex and brainstem

    Adv. Neurol.

    (1975)
  • AndradeR. et al.

    Neurotensin selectively activates dopaminergic neurons in the substantia nigra

    Soc. Neurosci. Abstr.

    (1981)
  • AroninN. et al.

    Neurotensin

  • BasbaumA.I. et al.

    The origin of descending pathways in the dorsolateral funiculus of the spinal cord of the cat and rat: pain modulation

    J. comp. Neurol.

    (1979)
  • BasbaumA.I. et al.

    Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry

    A. Rev. Neurosci.

    (1984)
  • Beheim-SchwarzbachD.

    Pathokline Niger-Veränderungen

    J. Hirnforsch.

    (1956)
  • BergerK.

    Semiquantitative Untersuchungen zur Verteilung der Neurophysin-Immunreactivität im Gehirn schizophrener Patienten

    Thesis

    (1987)
  • BernheimerH. et al.

    Verteilung des 5-Hydroxytryptamins (Serotonin) im Gehirn des Menschen und sein Verhalten bei Patienten mit Parkinson-Syndrom

    Klin. Wschr.

    (1961)
  • BernheimerH. et al.

    Zur Biochemie des Parkinson-Syndroms des Menschen. Einfluβ der Monoaminoxydase-Hemmer-Therapie auf die Konzentration des Dopamins, Noradrenalins und 5-Hydroxytryptamins im Gehirn

    Klin. Wschr.

    (1963)
  • BirkmayerW. et al.

    Serotonin and extrapyramidal disorders

  • BisetteG. et al.

    Hypothermia and intolerance to cold induced by intracisternal administration of the hypothalamic peptide neurotensin

    Nature

    (1976)
  • BrownD.R. et al.

    Neurotensin

    Br. med. Bull.

    (1982)
  • Buttlar-BrentanoK.v.

    Das Parkinsonsyndrom im Lichte der lebensgeschichtlichen Veränderungen des Nucleus basalis

    J. Hirnforsch.

    (1955)
  • ClineschmidtB.V. et al.

    Antinociceptive effects of neurotensin and neurotensin-related peptides

  • CrosbyE.C. et al.

    Correlative Anatomy of the Nervous System

    (1962)
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