Somatostatin-14 and somatostatin-28 inhibit calcium currents in rat neocortical neurons
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Cited by (84)
Somatostatin in the dentate gyrus
2007, Progress in Brain ResearchCitation Excerpt :This complexity in signaling is of course not unique to SST receptors, and simply because SST receptors have been shown that they can couple to a pathway in an artificial system, it does not necessarily follow that they do couple to these pathways to mediate their important physiological effects. Surprisingly few studies have addressed modulation of signaling pathways by SST in the brain, aside from its well-known actions on K+ and Ca2+ channels (Mihara et al., 1987; Inoue et al., 1988; Ikeda and Schofield, 1989; Wang et al., 1990a, b; Meriney et al., 1994; Connor et al., 1997; Sodickson and Bean, 1998). Inhibition of cAMP by SST in membranes from several brain regions has been observed, including cortex and hippocampus (Raynor and Reisine, 1992; Blake, 2001).
FK962, a novel enhancer of somatostatin release, exerts cognitive-enhancing actions in rats
2005, European Journal of PharmacologySomatostatin receptors
2003, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :Both peptide isoforms were found to inhibit Ca2+ currents. But as to the regulation of K+ currents, not only did one study show lack of cross-desensitisation to SRIF-14 and SRIF-28; apparently, in another study, the two peptides also induced opposite effects on K+ currents [362,372,373]. As a rule, it is hard to make sense of such transmitter-specific transduction originating from the same receptors.
Endogenous somatostatin receptors mobilize calcium from inositol 1,4,5-trisphosphate-sensitive stores in NG108-15 cells
2003, Brain ResearchCitation Excerpt :Five somatostatin receptor genes have been cloned. Some or all of these receptor subtypes have been observed to inhibit adenylate cyclase [53], activate K+ channels [47], and inhibit voltage-dependent Ca2+ channels [50]. These inhibitory actions underlie the decrease in neurotransmitter release and the reduced cellular excitability produced by somatostatin.
Somatostatin modulates Ca<sup>2+</sup> currents in neostriatal neurons
2002, Neuroscience