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2021, Neuroscience and Biobehavioral ReviewsTargeted overexpression of glutamate transporter-1 reduces seizures and attenuates pathological changes in a mouse model of epilepsy
2021, Neurobiology of DiseaseCitation Excerpt :The occurrence of neurochemical modulation in the contralateral hippocampus has been observed following unilateral injection of kainic acid. Following unilateral injections of kainic acid, delayed neuronal death and astrogliosis are observed in the contralateral hippocampus (Hubbard et al., 2016; Magloczky and Freund, 1995). Our data suggest that although GLT-1 upregulation is localized to the ipsilateral hippocampus, it contributes to neuroprotection in the contralateral hippocampus at early time points in epileptogenesis.
Significance of horizontal propagation of synchronized activities in human epileptic neocortex investigated by optical imaging and immunohistological study
2013, Epilepsy ResearchCitation Excerpt :Cortical distributions of CB, CR-positive neurons in layers II and III and PV-positive neurons in layers II–V in the present study were compatible with those in previous reports (DeFelipe, 1997, 1999; Zaitsev et al., 2005), but we found only that PV-positive cells showed significantly lower expression in epileptic than in non-epileptic cortices. Similar results have also been obtained in studies on animal epilepsy models or human hippocampus and cortical tissues (Best et al., 1993; Buckmaster and Dudek, 1997; Magloczky and Freund, 1995; Zhu et al., 1997). Considering the axonal terminations of PV positive neurons being oriented rather horizontally (Hendry and Jones, 1991; Lund and Lewis, 1993), we speculate that the decrease in PV-positive cells leads to a decrease in the regulation of excitatory spreading in the horizontal direction among pyramidal neurons.
Preferential inactivation of SCN1A in parvalbumin interneurons increases seizure susceptibility
2013, Neurobiology of DiseaseCitation Excerpt :Loss of PV interneurons has also been seen following chemically (Buckmaster and Dudek, 1997) and electrically induced seizures (Gorter et al., 2001). In addition, reduced PV immunoreactivity has been found in several rodent models of epilepsy (Magloczky and Freund, 1995; Scotti et al., 1997; Sloviter et al., 2003) and following recurrent hyperthermia-induced seizures (Kwak et al., 2008). Clinically, patients with intractable temporal lobe epilepsy also show reduced PV expression in resected neocortex (de Lanerolle et al., 1989; Marco et al., 1996).