A tetrodoxin-insensitive sodium current initiates burst firing of neocortical neurons
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Structure and function of splice variants of the cardiac voltage-gated sodium channel Na<inf>v</inf>1.5
2010, Journal of Molecular and Cellular CardiologyCitation Excerpt :The aim of this subsection is to review these studies in view of recent findings on the expression and properties of Nav1.5 splice variants. Neuronal expression of Nav1.5 was first detected in the rat cerebral cortex by RT-PCR [50], and TTX-resistant Na+ currents could be identified in neurons from entorhinal cortex, neocortex, hippocampus and striatum [51–53]. Nav1.5 transcripts were specifically localized in limbic structures of rat and human brain [42,43], and the respective channel protein was localized in various mouse brain regions including the cerebral cortex, thalamus, hypothalamus, and brain stem [41].
PYRAMIDAL CELLS | Intrinsic Mechanisms Contributing to Hyperexcitability of Human Epileptogenic Cortex
2009, Encyclopedia of Basic Epilepsy ResearchTheory of the normal waking EEG: From single neurones to waveforms in the alpha, beta and gamma frequency ranges
2007, International Journal of PsychophysiologyThe cardiac sodium channel mRNA is expressed in the developing and adult rat and human brain
2000, Brain ResearchCitation Excerpt :To date, the sodium channel genes that have been cloned from rat brain are TTX-S (I, II, III, and NaCh6 [4,16,27,38,50,53]). Although earlier studies failed to distinguish between the TTX-R and TTX-I sodium channel currents, several studies suggest that both kinds of current exist in the CNS [14,31,43,52,58,60]. However, the genes responsible for the TTX-R and the TTX-I currents in the CNS have not yet been identified.