Activity-dependent slowing of conduction velocity provides a method for identifying different functional classes of c-fibre in the rat saphenous nerve
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Cited by (82)
Postoperative pain facilitates rat C-fibre activity-dependent slowing and induces thermal hypersensitivity in a sex-dependent manner
2022, British Journal of AnaesthesiaCitation Excerpt :The finding that vehicle, which normally has no effect on ADS, influences 10 Hz width change in females but not males, along with the proposed function of ADS as a memory trace of previous levels of activity,68 may further support our observation of sex-specific differences in functional axonal NaV1.7/NaV1.8 ratio under normal conditions. This is further supported by studies demonstrating that different C-fibre subpopulations exhibit different amounts of ADS24,26 with pharmacology suggesting differential NaV channel subtype expression profiles.69,70 The TTX-induced changes in C-fibre ADS were altered by incision as assessed by latency and width change in both sexes (Figs 3 and 4).
Multisite silicon probes enable simultaneous recording of spontaneous and evoked activity in multiple isolated C-fibres in rat saphenous nerve
2022, Journal of Neuroscience MethodsCitation Excerpt :These developments have been extended with the advent of microneurography, enabling equivalent recordings in humans with simultaneous psychophysical measurements (see Vallbo, 2018 for review). Further refinements have included: the ‘marking technique’ to overcome issues of low signal to noise(Schmidt et al., 1995; Torebjork and Hallin, 1974); An ex-vivo preparation which provides greater flexibility for pharmacological manipulation (Reeh, 1986; Zimmermann et al., 2009); and the observation that specific sub populations of nociceptors alter their conduction velocity to differing extents during high frequency stimulation(Gee et al., 1996; Serra et al., 2004; Weidner et al., 1999). Despite these advances, the basic principle of using a single active electrode to make a differential recording in the peripheral nervous system, either in animals or people, has not changed in nearly 70 years (Vallbo, 2018).
5.10 - Neurotrophins and Pain
2020, The Senses: A Comprehensive Reference: Volume 1-7, Second EditionUltrasound-guided, open-source microneurography: Approaches to improve recordings from peripheral nerves in man
2018, Clinical NeurophysiologyCitation Excerpt :All threshold crossings following stimulation were then plotted as their latency after the stimulus against the time of the stimulus. Characteristic constant latency threshold crossings, which slowed with increasing stimulus frequency, could then be recognised as likely C nociceptor action potentials (Gee et al., 1996, Serra et al., 1999) These were then isolated from the noise using the Matlab function Selectdata. Isolation of these characteristic latency responses then allowed for isolation of the individual action potential profiles.