ArticleInfluence of nitric oxide synthase inhibition on the development of rapid tolerance to ethanol
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Tolerance to alcohol: A critical yet understudied factor in alcohol addiction
2021, Pharmacology Biochemistry and BehaviorCitation Excerpt :Male rats that were intracerebroventricularly treated with nitric oxide donors developed greater rapid alcohol tolerance in the tilt-plane test (Wazlawik and Morato, 2003). Male rats that received intraperitoneal or intracerebroventricular injections of nitric oxide synthase inhibitors before but not after alcohol administration did not exhibit rapid alcohol tolerance in the tilt-plane test (Khanna et al., 1993b; Khanna et al., 1995b; Wazlawik and Morato, 2002). Nitric oxide synthase inhibitors that were administered before but not after alcohol administration also blocked the enhancement of rapid tolerance by the NMDA receptor agonist cycloserine (Khanna et al., 1995a).
Effects of chronic ethanol consumption on the expression of GLT-1 and neuroplasticity-related proteins in the nucleus accumbens of alcohol-preferring rats
2020, Brain Research BulletinCitation Excerpt :The expression of BDNF and Arc are regulated by multiple signaling pathways, including intracellular and extracellular nitric oxide (NO) pathways (Riccio et al., 2006). Nitric oxide synthase (NOS), specifically the neuronal isoform (nNOS), is highly implicated in the development of tolerance (Khanna et al., 1993; Khanna et al., 1995) and sensitization (Itzhak and Martin, 2000; Santos-Rocha et al., 2018) to ethanol. Additionally, chronic ethanol exposure stimulates N-methyl-D-aspartate (NMDA) receptors, which are linked to nNOS via the post-synaptic density protein-95 (PSD-95) (Sattler et al., 1999).
Effects of sildenafil treatment on the development of tolerance to diazepam-induced motor impairment and sedation in mice
2010, Pharmacological ReportsCitation Excerpt :This result suggests that the development of tolerance is associated with various complex adaptive mechanisms [4, 40]. A wealth of data support the hypothesis that NO may be involved in the development of tolerance to substances of abuse, such as opioids, ethanol, nicotine and psycho-stimulants [3, 20, 22, 23, 40, 45]. Treatment with NOS inhibitors diminishes the symptoms of morphine abstinence and the development of tolerance to the analgesic effects of opioids [23, 40].
Interactions of alcohol and nitric-oxide synthase in the brain
2005, Brain Research ReviewsFormation of ethyl nitrite in vivo after ethanol administration
2004, AlcoholCitation Excerpt :Nitric oxide participates in many biologic functions, such as regulation of vascular tone, modulation of neurotransmission, and host defense reaction and cytotoxicity. There are many examples of the interaction between ethanol and NO (Adams & Cicero, 1998; Calapai et al., 1996; Crews et al., 1998; Ferreira et al., 1999; Khanna et al., 1995). Because NO readily reacts with compounds to form NO-derived substances, the possibility that it might also react with ethanol in vivo and contribute to the effects of ethanol was the rationale for our conducting the current study.
Changes of GABA<inf>A</inf> receptor binding and subunit mRNA level in rat brain by infusion of NOS inhibitor
2002, Brain ResearchCitation Excerpt :Inhibitors of NOS delay the development of tolerance to and withdrawal from ethanol. By contrast, NO donors accentuate the severity of expression of withdrawal syndrome [1,19,20]. Furthermore, it has been suggested that GABAA receptors efficiently control the NMDA/NO pathway in the cerebellum in vivo [9].