ArticleSerotonin 1B receptor regulation after dorsal subiculum deafferentation
References (34)
- et al.
The mouse 5-hydroxytryptamine1B receptor is localized predominantly on axon terminals
Neuroscience
(1994) - et al.
Spatial problem solving in a wheel-shaped maze: Quantitative and qualitative analyses of the behavioural changes following damage to the hippocampus in the rat
Behav. Brain Res.
(1991) - et al.
Demonstration of caudally directed hippocampal efferents in the rat by intracellular injection of horseradish peroxidase
Brain Res.
(1981) - et al.
The pharmacology of the terminal 5HT autoreceptors in mammalian brain: Evidence for species differences
Trends Pharmacol. Sci.
(1989) On the role of the hippocampus in learning and memory in the rat
Behav. Neural. Biol.
(1993)- et al.
Cholinergic terminals in rat hippocampus possess 5-HT1B receptors mediating inhibition of acetylcholine release
Eur. J. Pharmacol.
(1986) - et al.
Central serotonin1A receptors: Respective distribution of encoding mRNA, receptor protein and binding sites by in situ hybridization histochemistry, radioimmunohistochemistry and autoradiographic mapping in the rat brain
Neurochem. Int.
(1991) - et al.
A new system for computer assisted quantitative receptor autoradiography
J. Neurosci. Methods
(1990) - et al.
5-HT1D receptors in the guinea pig brain: Pre- and postsynaptic localizations in the striatonigral pathway
Brain Res.
(1990) - et al.
Organization of CA1 projections to the subiculum: A Phal-L analysis in the rat
Hippocampus
(1991)
Acquisition of a complex place task in rats with selective ibotenate lesions of hippocampal formation: Combined lesions of subiculum and entorhinal cortex versus hippocampus
Behav. Neurosci.
Biochemical and pharmacological characterization of serotonin-O-carboxymethylglycyl[125I]iodotyrosinamide, a new radioiodinated probe for 5-HT1B and 5-HT1D binding sites
J. Neurochem.
Effects of retinal deafferentation on serotonin receptor types in the superfical grey layer of the superior colliculus of the rat
J. Chem. Neuroanat.
Autoradiographic characterisation and localisation of 5-HT1D compared to 5-HT1B binding sites in the rat brain
Naunyn Schmiedebergs Arch. Pharmacol.
Polarized sorting of glypiated proteins in hippocampal neurons
Nature
Some intrinsic connections of the hippocampus in the rat: An experimental analysis
J. Comp. Neurol.
Effects of serotonin on retinotectal-, corticotectal-, and glutamate-induced activity in the superior colliculus of the hamster
J. Neurophysiol.
Cited by (29)
Cellular effects of serotonin in the CNS
2020, Handbook of Behavioral NeuroscienceCitation Excerpt :This effect appears to be signaled by 5-HT4 receptors, but the precise mechanisms by which these receptors gate the plasticity of CA3-CA1 glutamate synapses remain to be determined. Finally, pyramidal neurons of the CA1, but not the CA3 field, express 5-HT1B receptors that are targeted to their axonal projection terminals located principally in the subiculum (Ait Amara, Segu, Naili, & Buhot, 1995). Activation of these receptors inhibits glutamate-mediated synaptic transmission in this region (Boeijinga & Boddeke, 1993) (Fig. 15.1) by reducing the probability of glutamate release at individual synaptic terminals.
Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats
2013, Pharmacology Biochemistry and BehaviorCitation Excerpt :Brain 5-HT1B receptors function as inhibitory autoreceptors on serotonergic neurons and as heteroreceptors on neurons of other neurotransmitters such as ACh and glutamate (Pazos and Palacios, 1985; Olivier and Oorschot, 2005). In the dorsal subiculum, 5-HT1B receptors are located on CA1 pyramidal axon terminals as inhibitory heteroreceptors (Ait et al., 1995), and activation of these receptors attenuates glutamate transmission in the hippocampus (Boeijinga and Boddeke, 1996; Mlinar et al., 2003). Administration of a selective 5-HT1B receptor antagonist NAS-181 caused a dose-dependent increase in ACh levels in the frontal cortex and ventral hippocampus of freely moving rats (Hu et al., 2007).
Cellular Effects of Serotonin in the CNS
2010, Handbook of Behavioral NeuroscienceCitation Excerpt :This paradox was resolved with the demonstration that the co-activation of 5-HT1A and 5-HT4 receptors resulted in a large change in neuronal gain, a measure of how neurons encode excitatory input into firing output, such that weak excitatory stimuli are suppressed while strong stimuli are facilitated (Andrade and Nicoll, 1987). Finally, pyramidal neurons of the CA1, but not the CA3, field express 5-HT1B receptors that are targeted to their axonal projection terminals located in the subiculum (Ait et al., 1995). Activation of these receptors inhibits glutamate-mediated synaptic transmission in this region (Boeijinga and Boddeke, 1993) by reducing the probability of glutamate release at individual synaptic terminals (Figure 2E).
Electrophysiology of Serotonin Receptors
2010, Handbook of Behavioral NeuroscienceCitation Excerpt :The CA1 pyramidal neurons project both to other CA1 pyramidal cells in the stratum radiatum and to the subiculum. Knife-cut lesions disrupting the CA1/subicular synapse and CA1 chemical lesions causing a deafferentation of both the CA1/subicular and the CA1/CA1 synapse decrease 5-HT1B receptor binding (Amara et al., 1995, 2001). Another region with relatively weak 5-HT1B receptor mRNA expression yet strong 5-HT1B receptor binding is the subthalamic nucleus, where both IPSCs and EPSCs are inhibited via activation of 5-HT1B receptors.
Blockade of 5-HT<inf>1B</inf> receptors facilitates contextual aversive learning in mice by disinhibition of cholinergic and glutamatergic neurotransmission
2008, NeuropharmacologyCitation Excerpt :Hippocampal 5-HT1B heteroreceptors are located in positions to control both glutamatergic and cholinergic transmission. Previous studies mainly investigated the location of 5-HT1B receptors on glutamatergic neurons, i.e. terminals of CA1 pyramidal cells in major output projections to the subiculum (Ait Amara et al., 1995, 2001; Boeijinga and Boddeke, 1996; Boschert et al., 1994). The majority of the mRNA-encoding 5-HT1B receptors synthesised in CA1 pyramidal cells migrate to CA1 axon terminals located in the stratum oriens and dorsal subiculum (Boeijinga and Boddeke, 1996).