Outer hair cell electromotility: The sensitivity and vulnerability of the DC component
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Cited by (76)
Voltage Does Not Drive Prestin (SLC26a5) Electro-Mechanical Activity at High Frequencies Where Cochlear Amplification Is Best
2019, iScienceCitation Excerpt :Intriguing results on basilar membrane tuning have been obtained in prestin knock-out/in mice that may point to possible mechanisms of OHC action (MelladoLagarde et al., 2008). Alternatively, a rectified DC component of prestin activity (Evans et al., 1991; Santos-Sacchi, 1989) could contribute to effects on high-frequency tuning, as Vavakou et al. (Vavakou et al., 2019) have intimated. Finally, global hydromechanical influences of the OHC may be at play (He et al., 2018).
Motile responses of cochlear outer hair cells stimulated with an alternating electrical field
2011, Hearing ResearchCitation Excerpt :However, voltage clamp limited frequency response makes it ineffective at the kHz range, the key domain for acoustic stimuli (Santos-Sacchi, 1992). An alternative approach, termed the microchamber (Dallos et al., 1993; Evans et al., 1989, 1991), bypasses patch-clamp limitation by using suction pipettes. OHCs can be drawn to varying extents into a suction pipette with an internal diameter closely matching the cell diameter.
A mechanism for active hearing
2007, Current Opinion in NeurobiologyCitation Excerpt :This electromotile response is sometimes called reverse transduction to distinguish it from forward, mechanical-to-electrical transduction. OHCs elongate when they are depolarized, and shorten when hyperpolarized [14] in a nonlinear manner [15,16]. In the isolated cochlea, the cochlear partition distorts in response to electrically driven OHC length changes and produces place-specific vibration of the BM [17].
Mouse outer hair cells lacking the α9 ACh receptor are motile
2004, Developmental Brain Research