Intracochlear salicylate reduces low-intensity acoustic and cochlear microphonic distortion products☆
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Sodium salicylate potentiates the GABA<inf>B</inf>-GIRK pathway to suppress rebound depolarization in neurons of the rat's medial geniculate body
2016, Hearing ResearchCitation Excerpt :Sodium salicylate (NaSal) can cause tinnitus in humans (Halla and Hardin, 1988; Myers and Bernstein, 1965; Myers et al., 1965) and in laboratory animals (Guitton et al., 2003; Jastreboff et al., 1988; Mongan et al., 1973; Stolzberg et al., 2012). In attempts to understand the underlying mechanisms, researchers have extensively studied functional alterations caused by NaSal in the cochlea (Cazals et al., 1998; Durrant et al., 1998; Evans and Borerwe, 1982; Fitzgerald et al., 1993; Kujawa et al., 1992; Lobarinas et al., 2006; Muller et al., 2003), central auditory pathways (Chen et al., 2013; Chen and Jastreboff, 1995; Eggermont and Kenmochi, 1998; Jastreboff and Sasaki, 1986; Patel and Zhang, 2014; Stolzberg et al., 2012; Wallhausser-Franke, 1997) and non-auditory brain regions (Chen et al., 2012; Wallhausser-Franke et al., 2003). In particular, neuropharmacological actions of NaSal have been examined in detail across different central auditory regions, including the cochlear nucleus (Basta et al., 2008; Wei et al., 2010), the inferior colliculus (Chen and Jastreboff, 1995; Jastreboff and Sasaki, 1986), the medial geniculate body (MGB) (Basta et al., 2008; Su et al., 2012) and the auditory cortex (Su et al., 2009; Yang et al., 2007).
Ear
2013, Haschek and Rousseaux's Handbook of Toxicologic PathologyEar
2013, Haschek and Rousseaux's Handbook of Toxicologic Pathology, Third Edition: Volume 1-3Salicylate-induced peripheral auditory changes and tonotopic reorganization of auditory cortex
2011, NeuroscienceCitation Excerpt :The major effect of systemic salicylate injection on cochlear function in rats observed in this study was a significant alteration in the profile of peripheral input; low and high frequencies became less sensitive following salicylate administration leaving 16 kHz as the dominant input frequency (Fig. 1). Salicylate's effects on OHC function have been evaluated following cochlear perfusion in the guinea pig (Kujawa et al., 1992) as well as systemic administration in the rat (Wang et al., 1984; Ralli et al., 2010). In agreement with the results presented here, both of these studies showed a decrease in DPOAE following salicylate administration at low to moderate intensities (Figs. 1 and 3a).
A method for intracochlear drug delivery in the mouse
2006, Journal of Neuroscience MethodsInner ear drug delivery via a reciprocating perfusion system in the guinea pig
2005, Journal of Controlled Release
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A preliminary report was presented at the Midwinter Research Meeting of the Association for Research in Otolaryngology in February 1991.