Short communicationChromosomal localization of the human homeo box-containing genes, EN1 and EN2
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The Genetics of Pigment Dispersion Syndrome and Pigmentary Glaucoma
2013, Survey of OphthalmologyCitation Excerpt :Autosomal dominant inheritance of the trait was supported by the presence of affected individuals in each generation and equal numbers of affected men and women. The gene itself has not yet been discovered, and this linkage has not been replicated to date, but candidate genes mapped to this region of chromosome 7 include a homeobox gene involved in the development of the forebrain,94 a muscarinic acetylcholine receptor gene,19 the human endothelial nitric oxide synthase gene NOS3,134 and a gene associated with human cyclops.52 Also, the gene responsible for phenylthiocarbamide tasting has been mapped to the telomeric portion of the long arm of chromosome 7 and could serve as a genetic marker for this region.30
A question of balance: A proposal for new mouse models of autism
2005, International Journal of Developmental NeuroscienceCitation Excerpt :As mentioned previously, chromosomes 2 and 7 are among the top candidate regions for autism susceptibility genes. Mapping adjacent to the region of interest on chromosome 7 is Engrailed-2 (EN2), located at 7q36 (Logan et al., 1989; Poole et al., 1989). Based on its location as well as role in CNS development, EN2 has been investigated for a link to autism.
Cerebellum development and schizophrenia: An association study of the human homeogene Engrailed 2
2004, Psychiatry Research