Short communicationLocalization of the human phosphatidylinositol-specific phospholipase C β3 gene (PLCB3) within chromosome band 11q13
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Specificity and structural requirements of phospholipase C-β stimulation by Rho GTPases versus G protein βγ dimers
2003, Journal of Biological ChemistryCitation Excerpt :Construction of recombinant baculoviruses for expression of the bovine PLCβ1 and human PLCβ2 have been described (26, 20). The cDNA of human PLCβ3 (27) was cloned into the EcoRI site of the baculovirus transfer vector pVL1393 (Invitrogen, Carlsbad, CA). The cDNAs of C-terminally deleted PLCβ constructs were generated such that the proteins retained their C-terminal-most portions (GENPGKEFDTPL, PLCβ1; QDPLIAKADAQESRL, PLCβ2; and GADSESQEENTQL, PLCβ3), which had been used as synthetic peptides to generate PLCβ subtype-specific antisera in rabbits (28).
Gβ<inf>5</inf>γ<inf>2</inf> is a highly selective activator of phospholipid-dependent enzymes
2000, Journal of Biological ChemistryCitation Excerpt :PLCβ2Δ, a deletion mutant of human PLCβ2 lacking a C-terminal region necessary for stimulation by Gαq, is indistinguishable from wild-type PLCβ2 in terms of its interaction with PI-4,5-P2, Ca2+, and Gβγ dimers (22). The cDNA of human PLCβ3 cloned into theEcoRI site of a pBluescript vector was kindly provided by M. van Asseldonk (Department of Human Genetics, University Hospital Nijmegen, Nijmegen, The Netherlands) (25). The construct was digested with EcoRI and ligated into this site in the pVL1393 transfer vector.
Fine mapping of the human renal oncocytoma-associated translocation (5;11)(q35;q13) breakpoint
1997, Cancer Genetics and CytogeneticsStructural organization and expression of the human phosphatidylinositol-specific phospholipase C β-3 gene
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