Regular articleSuppression of specific antibody production by inescapable shock: Stability under varying conditions
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2014, Brain, Behavior, and ImmunityCitation Excerpt :With Moni Fleshner, a young graduate student working with Maier and I, we developed an enzyme immunoassay for detecting antibodies to KLH following immunization. We found that under a variety of different conditions, uncontrollable tail shock was consistently associated with reduced specific antibody levels to KLH compared to control conditions (Laudenslager et al., 1988). Fleshner went onto elegantly show that individual differences in the KLH response could be accounted for by differences in the behavior of individual rats responding to the behavioral challenge of territorial intrusion (Fleshner et al., 1989).
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2013, Brain, Behavior, and ImmunityCitation Excerpt :These observations in the human literature fueled mechanistic animal stress research that initially relied on crude in vitro measures of T and B cell mitogen-stimulated proliferation, but then rapidly progressed to better in vivo measures of specific immunity. For example, using a well-established animal model of stress (uncontrollable tailshock) that had been previously documented to produce anxiety/depressive-like behaviors and cognitive deficits (Maier, 1991, 1984; Maier and Watkins, 2005; Strong et al., 2011, 2009), we published several studies documenting a long-term suppression in the generation of KLH specific, T-cell dependent, antibody responses (Fleshner et al., 1996, 2001, 1998; Gazda et al., 2003; Laudenslager et al., 1988). There is also a rich literature demonstrating that exposure to intense acute stressors or chronic/repeated stressors, suppresses specific anti-viral host defense (Kusnecov et al., 1992; Padgett et al., 1998; Sheridan et al., 1998, 2000) and anti-tumor immunity (Ben-Eliyahu et al., 2007, 2000), making organisms vulnerable to pathogen-evoked disease and cancer.
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