Neuron
ArticleTTX-sensitive and TTX-insensitive sodium channel mRNA transcripts are independently regulated in adult skeletal muscle after denervation
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Fibrillation potentials of denervated rat skeletal muscle are associated with expression of cardiac-type voltage-gated sodium channel isoform Nav1.5
2012, Clinical NeurophysiologyCitation Excerpt :The cardiac sodium channel Nav1.5, recently known as one of the causative molecules of genetic arrhythmias such as Brugada syndrome, is not present in matured skeletal muscle (Kapplinger et al., 2010). However, Nav1.5 expresses on early development and denervation in skeletal muscle, responsible for tetrodotoxin-resistant sodium current (Rogart et al., 1989; Kallen et al., 1990; Yang et al., 1991; Lupa et al., 1995). In our study, an nav1.5-specific signal was detected on northern blot analysis at the same time as fibrillation potentials appeared.
Accumulation of severely atrophic myofibers marks the acceleration of sarcopenia in slow and fast twitch muscles
2011, Experimental GerontologyCitation Excerpt :Furthermore, in other experiments presented recently in abstract form (Rowan et al., 2010), we found that denervation is the most likely explanation for the dramatic accumulation of the very small muscle fibers in aged muscle. Specifically, our data showed that fibers positive for the sodium channel isoform Nav1.5 (a marker of denervation in adult muscle; Kallen et al., 1990; Yang et al., 1991) are much smaller than Nav1.5 negative fibers and that the latter fibers are ≤ 10% smaller than young adult muscle, suggesting that denervation is the primary cause of fiber atrophy in aging muscle (Rowan et al., manuscript in review). Clearly, additional study is warranted to further critically assess the innervation status of the severely atrophied fibers, and their impact on whole muscle phenotypes in aging muscle.
Mechanisms of Neuromuscular Dysfunction in Critical Illness
2008, Critical Care ClinicsCitation Excerpt :In normal mature skeletal muscle, only the Nav1.4 sodium channel is present. Following denervation or steroid treatment, however, the Nav1.5 sodium channel is also expressed [56,57]. It has been found in tissue culture that Nav1.5 sodium channels inactivate at more hyperpolarized membrane potentials than Nav1.4 sodium channels [58,59].
Voltage-dependent Na<sup>+</sup> channel phenotype changes in myoblasts. Consequences for cardiac repair
2007, Cardiovascular ResearchMature Myotubes Generated From Human-Induced Pluripotent Stem Cells Without Forced Gene Expression
2022, Frontiers in Cell and Developmental BiologyEpigenetic changes governing scn5a expression in denervated skeletal muscle
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