Neuron
Volume 8, Issue 2, February 1992, Pages 307-322
Journal home page for Neuron

Article
Genes necessary for directed axonal elongation or fasciculation in C. elegans

https://doi.org/10.1016/0896-6273(92)90297-QGet rights and content

Abstract

The outgrowth of single axons through different cellular environments requires distinct sets of genes in the nematode C. elegans. Three genes are required for the pioneering circumferential outgrowth of identified motor neuron axons between the lateral hypodermal cell membrane and the basal lamina. Three other genes are required for the longitudinal outgrowth of these axons along preexisting axon bundles as well as for the fasciculation of axons within these neuron bundles. Five additional genes are required for circumferential outgrowth, longitudinal outgrowth, and fasciculation; mutations in three of these genes disrupt axon ultrastructure, suggesting that they function in axon formation rather than in axon guidance.

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    Present address: Bigelow Laboratory for Ocean Sciences, West Boothbay Harbor, Maine 04575.

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